Biology and therapeutic targeting of vascular endothelial growth factor A
L Pérez-Gutiérrez, N Ferrara - Nature Reviews Molecular Cell Biology, 2023 - nature.com
The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …
process in which several families of regulators have been implicated. Among these, vascular …
Preeclampsia: pathophysiology, challenges, and perspectives
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …
Pre-eclampsia: pathogenesis, novel diagnostics and therapies
EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …
Placental growth factor and pre-eclampsia
Placental growth factor (PlGF) is an increasingly important molecule in the prediction,
diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental …
diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental …
[HTML][HTML] Preeclampsia: A review of the pathogenesis and possible management strategies based on its pathophysiological derangements
AAF El-Sayed - Taiwanese Journal of Obstetrics and Gynecology, 2017 - Elsevier
This review is divided into three parts. The first part briefly describes the pathogenesis of
preeclampsia. This is followed by reviewing previously reported management strategies of …
preeclampsia. This is followed by reviewing previously reported management strategies of …
RNAi modulation of placental sFLT1 for the treatment of preeclampsia
Preeclampsia is a placentally induced hypertensive disorder of pregnancy that is associated
with substantial morbidity and mortality to mothers and fetuses. Clinical manifestations of …
with substantial morbidity and mortality to mothers and fetuses. Clinical manifestations of …
Circulating angiogenic factor levels in hypertensive disorders of pregnancy
R Thadhani, E Lemoine, S Rana… - NEJM …, 2022 - evidence.nejm.org
Background Among women with hypertensive disorders of pregnancy, biomarkers may
stratify risk for develo** preeclampsia with severe features (sPE). Methods Across 18 US …
stratify risk for develo** preeclampsia with severe features (sPE). Methods Across 18 US …
A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre‐eclampsia: Compiled by the …
Pre-eclampsia is a multisystem disorder that typically affects 2%–5% of pregnant women
and is one of the leading causes of maternal and perinatal morbidity and mortality …
and is one of the leading causes of maternal and perinatal morbidity and mortality …
Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia
There has been increasing research momentum to identify new therapeutic agents for the
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …
Targeting angiogenesis and lymphangiogenesis in kidney disease
K Tanabe, J Wada, Y Sato - Nature Reviews Nephrology, 2020 - nature.com
The kidney is permeated by a highly complex vascular system with glomerular and
peritubular capillary networks that are essential for maintaining the normal functions of …
peritubular capillary networks that are essential for maintaining the normal functions of …