The predominant inhibitory neurotransmitter in the brain, γ-aminobutyric acid (GABA), acts at
ionotropic GABAA receptors to counterbalance excitation and regulate neuronal firing …

The major cause of disability in schizophrenia is cognitive impairment, which remains
largely refractory to existing treatments. This reflects the fact that antipsychotics and other …

Pharmacologically-induced persistent hippocampal γ oscillation in area CA3 requires
activation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) …

Background Abnormalities in dorsolateral prefrontal cortex (DLPFC) oscillations are
neurophysiological signatures of schizophrenia thought to underlie its cognitive deficits …

Schizophrenia is a severe mental illness characterized by alterations in processes that
regulate both synaptic plasticity and functional connectivity between brain regions …

Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation
method that, through its manipulation of endogenous oscillations, can affect cognition in …

Rationale Preclinical studies indicate that high-frequency oscillations, above 100 Hz (HFO:
100–170 Hz), are a potential translatable biomarker for pharmacological studies, with the …

Noncompetitive NMDA receptor (NMDAR) antagonists like phencyclidine (PCP) and
ketamine cause psychosis‐like symptoms in healthy humans, exacerbate schizophrenia …

Deficient gamma oscillations in prefrontal cortex (PFC) of individuals with schizophrenia
appear to involve impaired inhibitory drive from parvalbumin-expressing interneurons …

Nitropyrene (1-NP) is a neurodevelopmental toxicant. This study was to evaluate the impact
of exposure to 1-NP after weaning on anxiety-like behavior. Five-week-old mice were …