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Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …
the extracellular domain and signaling properties in the cytoplasmic domain. While most …
Angiogenesis as a hallmark of solid tumors-clinical perspectives
J Majidpoor, K Mortezaee - Cellular Oncology, 2021 - Springer
Background Angiogenesis is a key and early step in tumorigenesis, and is known as a
hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue …
hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue …
[HTML][HTML] The response and resistance to drugs in ovarian cancer cell lines in 2D monolayers and 3D spheroids
Ovarian cancer is the most common type of gynecologic cancer. One of the leading causes
of high mortality is chemoresistance, developed primarily or during treatment. Different …
of high mortality is chemoresistance, developed primarily or during treatment. Different …
The characteristics and the multiple functions of integrin β1 in human cancers
L Sun, S Guo, Y ** cutting-edge therapeutics in …
Identification of BGN and THBS2 as metastasis‐specific biomarkers and poor survival key regulators in human colon cancer by integrated analysis
Z He, J Lin, C Chen, Y Chen, S Yang… - Clinical and …, 2022 - Wiley Online Library
Background Colon cancer is the second leading cause of death worldwide. Exploring key
regulators in colon cancer metastatic progression could lead to better outcomes for patients …
regulators in colon cancer metastatic progression could lead to better outcomes for patients …
Matrix metalloproteinase contribution in management of cancer proliferation, metastasis and drug targeting
Matrix metalloproteinases (MMPs) or matrixins, are members of a zinc-dependent
endopeptidase family. They cause remodeling of the extracellular matrix (ECM) leading to …
endopeptidase family. They cause remodeling of the extracellular matrix (ECM) leading to …