Glioblastoma and other primary brain malignancies in adults: a review
Importance Malignant primary brain tumors cause more than 15 000 deaths per year in the
United States. The annual incidence of primary malignant brain tumors is approximately 7 …
United States. The annual incidence of primary malignant brain tumors is approximately 7 …
Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours
A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …
Although the previous edition of this classification was published just 5 years earlier, in …
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma
Abstract Treatment of the tumor and dural margin with surgery and sometimes radiation are
cornerstones of therapy for meningioma. Molecular classifications have provided insights …
cornerstones of therapy for meningioma. Molecular classifications have provided insights …
Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies
One-fifth of meningiomas classified as benign by World Health Organization (WHO)
histopathological grading will behave malignantly. To better diagnose these tumors, several …
histopathological grading will behave malignantly. To better diagnose these tumors, several …
Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients
Meningiomas are the most common primary intracranial tumors in adults and are increasing
in incidence due to the aging population and increased access to neuroimaging. While most …
in incidence due to the aging population and increased access to neuroimaging. While most …
Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
Hedgehog signaling mediates embryologic development of the central nervous system and
other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular …
other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular …
Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features
Background Meningiomas, the most common primary intracranial tumors, can be separated
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …
Grade 3 meningioma survival and recurrence outcomes in an international multicenter cohort
OBJECTIVE Grade 3 meningioma represents a rare meningioma subtype, for which limited
natural history data are available. The objective of this study was to identify demographics …
natural history data are available. The objective of this study was to identify demographics …
Loss of p16 expression is a sensitive marker of CDKN2A homozygous deletion in malignant meningiomas
V Tang, R Lu, K Mirchia, J Van Ziffle, P Devine… - Acta …, 2023 - Springer
While meningiomas are generally benign, slow-growing tumors with excellent post-surgical
outcomes, a significant subset follows a more aggressive clinical course resistant to existing …
outcomes, a significant subset follows a more aggressive clinical course resistant to existing …
cIMPACT-NOW Update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas
Meningiomas are the most frequent primary intracranial tumors. Hence, they constitute a
major share of diagnostic specimens in neuropathology practice. The 2021 WHO …
major share of diagnostic specimens in neuropathology practice. The 2021 WHO …