Microbiome effects on immunity, health and disease in the lung

SD Shukla, KF Budden, R Neal… - Clinical & translational …, 2017 - Wiley Online Library
Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …

[HTML][HTML] COVID-19 and COPD: a narrative review of the basic science and clinical outcomes

A Higham, A Mathioudakis, J Vestbo… - European respiratory …, 2020 - Eur Respiratory Soc
The 2019 coronavirus disease (COVID-19) pandemic is caused by severe acute respiratory
syndrome-coronavirus-2 (SARS-CoV-2). Clinical outcomes, including mortality, are worse in …

Interplay between the lung microbiome and lung cancer

Q Mao, F Jiang, R Yin, J Wang, W ** and risk
stratification in chronic obstructive pulmonary disease (COPD), but few large longitudinal …

New anti-inflammatory targets for chronic obstructive pulmonary disease

PJ Barnes - Nature reviews Drug discovery, 2013 - nature.com
Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation of
the peripheral airways and lung parenchyma, which leads to progressive obstruction of the …

How inhaled corticosteroids target inflammation in COPD

S Lea, A Higham, A Beech… - European Respiratory …, 2023 - Eur Respiratory Soc
Inhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the
treatment of COPD. COPD has been previously described as a “corticosteroid-resistant” …

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

L Zuo, F He, GG Sergakis… - … of Physiology-Lung …, 2014 - journals.physiology.org
Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders
such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading …

The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD

JM Leung, PY Tiew, M Mac Aogáin, KF Budden… - …, 2017 - Wiley Online Library
ABSTRACT COPD is a major global concern, increasingly so in the context of ageing
populations. The role of infections in disease pathogenesis and progression is known to be …

A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD

TMA Wilkinson, E Aris, S Bourne, SC Clarke, M Peeters… - Thorax, 2017 - thorax.bmj.com
Background The aetiology of acute exacerbations of COPD (AECOPD) is incompletely
understood. Understanding the relationship between chronic bacterial airway infection and …

Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease

JA Wedzicha, SE Brill, JP Allinson, GC Donaldson - BMC medicine, 2013 - Springer
Exacerbations of chronic obstructive pulmonary disease (COPD) are important events that
carry significant consequences for patients. Some patients experience frequent …