Restraining the power of Proteolysis Targeting Chimeras in the cage: A necessary and important refinement for therapeutic safety
R Zhang, S **e, J Ran, T Li - Journal of Cellular Physiology, 2024 - Wiley Online Library
Abstract Proteolysis Targeting Chimeras (PROTACs) represent a significant advancement in
therapeutic drug development by leveraging the ubiquitin‐proteasome system to enable …
therapeutic drug development by leveraging the ubiquitin‐proteasome system to enable …
A patent review of von Hippel-Lindau (vhl)-recruiting chemical matter: E3 ligase ligands for PROTACs and targeted protein degradation (2019-present)
A Urbina, AJ Hallatt, J Robertson… - Expert Opinion on …, 2025 - Taylor & Francis
ABSTRACT Introduction The von Hippel-Lindau (VHL) E3 ubiquitin ligase has seen
extensive research due to its involvement in the ubiquitin proteasome system and role as a …
extensive research due to its involvement in the ubiquitin proteasome system and role as a …
Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability
H Wu, J Murray, N Ishisoko, A Frommlet… - Journal of Medicinal …, 2024 - ACS Publications
The von Hippel–Lindau (VHL) protein plays a pivotal role in regulating the hypoxic stress
response and has been extensively studied and utilized in the targeted protein degradation …
response and has been extensively studied and utilized in the targeted protein degradation …
Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers
SMARCA2 is an attractive synthetic lethal target in human cancers with mutated, inactivated
SMARCA4. We report herein the discovery of highly potent and selective SMARCA2 …
SMARCA4. We report herein the discovery of highly potent and selective SMARCA2 …
The role of HIF-1α/BNIP3/mitophagy in acrylonitrile-induced neuronal death in HT22 cells and mice: A potential neuroprotection target
J Hu, B Yang, Z Tao, J Chen, X Zhang, S Wang… - Chemico-Biological …, 2025 - Elsevier
Acrylonitrile (AN) is a widely utilized organic compound in the production of diverse
industrial synthetic materials. While acute exposure to AN can cause neurotoxicity, the …
industrial synthetic materials. While acute exposure to AN can cause neurotoxicity, the …
[HTML][HTML] Microalgae-Assisted Treatment of Wastewater Originating from Varied Sources, Particularly in the Context of Heavy Metals and Antibiotic-Resistant Bacteria
The increasing prevalence of heavy metals and antibiotic-resistant bacteria in wastewater
(WW) raises serious environmental and public health concerns. This study investigates the …
(WW) raises serious environmental and public health concerns. This study investigates the …
[HTML][HTML] Advancements in understanding the molecular mechanisms and clinical implications of Von Hippel-Lindau syndrome: A comprehensive review
Y Wang, J Song, S Zheng, S Wang - Translational Oncology, 2025 - Elsevier
Abstract Von Hippel-Lindau Syndrome (VHL) is a rare genetic disorder characterized by
tumors in multiple organs, including the kidneys, pancreas, and central nervous system. This …
tumors in multiple organs, including the kidneys, pancreas, and central nervous system. This …
Structural Considerations and Chemistry
S Dev, P Mohanty, P Jain - PROTAC-Mediated Protein …, 2024 - books.google.com
The druggability of protein targets and dose-dependent side effects present chal-lenges to
the search for efficient therapies through enzyme inhibition. The drug-gability of protein …
the search for efficient therapies through enzyme inhibition. The drug-gability of protein …
Structural Considerations and Chemistry of PROTACs
The druggability of protein targets and dose-dependent side effects present challenges to
the search for efficient therapies through enzyme inhibition. The druggability of protein …
the search for efficient therapies through enzyme inhibition. The druggability of protein …