Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

[HTML][HTML] White adipose tissue dysfunction in obesity and aging

M Reyes-Farias, J Fos-Domenech, D Serra… - Biochemical …, 2021 - Elsevier
Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …

The importance of dendritic cells in maintaining immune tolerance

C Audiger, MJ Rahman, TJ Yun, KV Tarbell… - The Journal of …, 2017 - journals.aai.org
Immune tolerance is necessary to prevent the immune system from reacting against self, and
thus to avoid the development of autoimmune diseases. In this review, we discuss key …

Regulatory B cells in cancer

D Michaud, CR Steward, B Mirlekar… - Immunological …, 2021 - Wiley Online Library
Tumorigenesis proceeds through discrete steps where acquisition of genetic lesions and
changes in the surrounding microenvironment combine to drive unrestricted neoplastic …

Mechanisms of Tolerance Induction by Dendritic Cells In Vivo

H Hasegawa, T Matsumoto - Frontiers in immunology, 2018 - frontiersin.org
Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune
responses and tolerance. DCs promote immune tolerance by participating in the negative …

Tolerance through education: how tolerogenic dendritic cells shape immunity

MP Domogalla, PV Rostan, VK Raker… - Frontiers in …, 2017 - frontiersin.org
Dendritic cells (DCs) are central players in the initiation and control of responses, regulating
the balance between tolerance and immunity. Tolerogenic DCs are essential in the …

Dendritic cells in the regulation of immunity and inflammation

C Qian, X Cao - Seminars in immunology, 2018 - Elsevier
As potent antigen-presenting cells, dendritic cells (DCs) comprise the most heterogeneous
cell population with significant cellular phenotypic and functional plasticity. They form a …

Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial

I Zubizarreta, G Flórez-Grau, G Vila, R Cabezón… - Proceedings of the …, 2019 - pnas.org
There are adaptive T-cell and antibody autoimmune responses to myelin-derived peptides
in multiple sclerosis (MS) and to aquaporin-4 (AQP4) in neuromyelitis optica spectrum …

Natural and induced tolerogenic dendritic cells

CA Iberg, D Hawiger - The Journal of Immunology, 2020 - journals.aai.org
Dendritic cells (DCs) are highly susceptible to extrinsic signals that modify the functions of
these crucial APCs. Maturation of DCs induced by diverse proinflammatory conditions …

Regulatory dendritic cells, T cell tolerance, and dendritic cell therapy for immunologic disease

S Ness, S Lin, JR Gordon - Frontiers in Immunology, 2021 - frontiersin.org
Dendritic cells (DC) are antigen-presenting cells that can communicate with T cells both
directly and indirectly, regulating our adaptive immune responses against environmental …