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Animal models for COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of
coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the …
coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the …
Organ-on-a-chip: a new paradigm for drug development
The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection
To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …
three highly pathogenic variants have emerged in the 21st century. The newest member of …
[HTML][HTML] Evolution of biochip technology: A review from lab-on-a-chip to organ-on-a-chip
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel
biomedical application for microfluidic based devices has emerged in recent years and …
biomedical application for microfluidic based devices has emerged in recent years and …
[HTML][HTML] SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery
Summary Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused
by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although …
by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although …
Application of 3D bioprinting in the prevention and the therapy for human diseases
Rapid development of vaccines and therapeutics is necessary to tackle the emergence of
new pathogens and infectious diseases. To speed up the drug discovery process, the …
new pathogens and infectious diseases. To speed up the drug discovery process, the …
Poor translatability of biomedical research using animals—a narrative review
The failure rate for the translation of drugs from animal testing to human treatments remains
at over 92%, where it has been for the past few decades. The majority of these failures are …
at over 92%, where it has been for the past few decades. The majority of these failures are …
Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip
Mechanical breathing motions have a fundamental function in lung development and
disease, but little is known about how they contribute to host innate immunity. Here we use a …
disease, but little is known about how they contribute to host innate immunity. Here we use a …
Human organs-on-chips for virology
While conventional in vitro culture systems and animal models have been used to study the
pathogenesis of viral infections and to facilitate development of vaccines and therapeutics …
pathogenesis of viral infections and to facilitate development of vaccines and therapeutics …