Animal models for COVID-19

C Muñoz-Fontela, WE Dowling, SGP Funnell, PS Gsell… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of
coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the …

Organ-on-a-chip: a new paradigm for drug development

C Ma, Y Peng, H Li, W Chen - Trends in pharmacological sciences, 2021 - cell.com
The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection

A Synowiec, A Szczepański… - Clinical microbiology …, 2021 - journals.asm.org
To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …

[HTML][HTML] Evolution of biochip technology: A review from lab-on-a-chip to organ-on-a-chip

N Azizipour, R Avazpour, DH Rosenzweig, M Sawan… - Micromachines, 2020 - mdpi.com
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel
biomedical application for microfluidic based devices has emerged in recent years and …

[HTML][HTML] SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

A Mulay, B Konda, G Garcia, C Yao, S Beil, JM Villalba… - Cell reports, 2021 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused
by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although …

Application of 3D bioprinting in the prevention and the therapy for human diseases

HG Yi, H Kim, J Kwon, YJ Choi, J Jang… - Signal Transduction and …, 2021 - nature.com
Rapid development of vaccines and therapeutics is necessary to tackle the emergence of
new pathogens and infectious diseases. To speed up the drug discovery process, the …

Poor translatability of biomedical research using animals—a narrative review

LJ Marshall, J Bailey, M Cassotta… - Alternatives to …, 2023 - journals.sagepub.com
The failure rate for the translation of drugs from animal testing to human treatments remains
at over 92%, where it has been for the past few decades. The majority of these failures are …

Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip

H Bai, L Si, A Jiang, C Belgur, Y Zhai, R Plebani… - Nature …, 2022 - nature.com
Mechanical breathing motions have a fundamental function in lung development and
disease, but little is known about how they contribute to host innate immunity. Here we use a …

Human organs-on-chips for virology

H Tang, Y Abouleila, L Si, AM Ortega-Prieto… - Trends in …, 2020 - cell.com
While conventional in vitro culture systems and animal models have been used to study the
pathogenesis of viral infections and to facilitate development of vaccines and therapeutics …