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Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
[HTML][HTML] Mechanisms and regulation of cellular senescence
L Roger, F Tomas, V Gire - International journal of molecular sciences, 2021 - mdpi.com
Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …
Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies
L Walcher, AK Kistenmacher, H Suo, R Kitte… - Frontiers in …, 2020 - frontiersin.org
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …
A guide to assessing cellular senescence in vitro and in vivo
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …
Hallmarks of senescence and aging
Sažetak The complex process of biological aging, as an intrinsic feature of living beings, is
the result of genetic and, to a greater extent, environmental factors and time. For many of the …
the result of genetic and, to a greater extent, environmental factors and time. For many of the …
Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies
J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …
[HTML][HTML] Epigenetic mechanisms of longevity and aging
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …
Cellular senescence: molecular targets, biomarkers, and senolytic drugs
Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …
Cellular senescence in cancer: clinical detection and prognostic implications
Cellular senescence is a state of stable cell-cycle arrest with secretory features in response
to cellular stress. Historically, it has been considered as an endogenous evolutionary …
to cellular stress. Historically, it has been considered as an endogenous evolutionary …
Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans
Aging leads to a progressive functional decline of the immune system, rendering the elderly
increasingly susceptible to disease and infection. The degree to which immune cell …
increasingly susceptible to disease and infection. The degree to which immune cell …