In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Objectives: Imbalance between excitation and inhibition and increased excitatory-inhibitory
(EI) ratio is a common mechanism in autism spectrum disorders (ASD) that is responsible for …

Ketamine has been found to have rapid and potent antidepressant activity. However, despite
the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor …

A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained
antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that …

Brains are constantly flooded with sensory information that needs to be filtered at the pre-
attentional level and integrated into endogenous activity in order to allow for detection of …

Importance A major goal of translational neuroscience is to identify neural circuit
abnormalities in neuropsychiatric disorders that can be studied in animal models to facilitate …

The functional optimization of neural ensembles is central to human higher cognitive
functions. When the functions through which neural activity is tuned fail to develop or break …

Evidence suggests that anomalous mismatch negativity (MMN) in schizophrenia is related to
glutamatergic abnormalities, possibly involving N-methyl-d-aspartate (NMDA) receptors …

Abnormal γ band activity is observed in patients with schizophrenia and disease models in
animals, and is suggested to underlie the psychosis and cognitive/perceptual deficits …

Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric
disorders; however, the basic underlying mechanisms of memory and altered states of …