Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

Apoptosis is widely known as programmed cell death eliciting no inflammatory responses.
The intricacy of apoptosis has been a focus of an array of researches, accumulating a wealth …

B-cell lymphoma extra large (BCL-XL) is a well-validated cancer target. However, the on-
target and dose-limiting thrombocytopenia limits the use of BCL-XL inhibitors, such as …

Various physiological processes involve appropriate tissue developmental process and
homeostasis-the pathogenesis of several diseases connected with deregulatory apoptosis …

Abstract PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug
development platform. However, most PROTACs have been generated empirically because …

Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …

Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …

Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally
derived from Artemisia annua L. The anti-malarial action of artemisinins involves the …