Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining

CY Chiang, M Ohashi, Y Tang - Natural product reports, 2023 - pubs.rsc.org
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

[HTML][HTML] Develo** fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity

X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

The Potency of Fungal-Fabricated Selenium Nanoparticles to Improve the Growth Performance of Helianthus annuus L. and Control of Cutworm Agrotis ipsilon

MA Amin, MA Ismail, AA Badawy, MA Awad, MF Hamza… - Catalysts, 2021 - mdpi.com
The application of green nanotechnology in agriculture has been receiving substantial
attention, especially in the development of new nano-fertilizers and nano-insecticides …

Advances and challenges in CRISPR/Cas-based fungal genome engineering for secondary metabolite production: A review

D Wang, S **, Q Lu, Y Chen - Journal of Fungi, 2023 - mdpi.com
Fungi represent an important source of bioactive secondary metabolites (SMs), which have
wide applications in many fields, including medicine, agriculture, human health, and many …

Penicillium chrysogenum, a Vintage Model with a Cutting-Edge Profile in Biotechnology

F Fierro, I Vaca, NI Castillo, RO García-Rico, R Chávez - Microorganisms, 2022 - mdpi.com
The discovery of penicillin entailed a decisive breakthrough in medicine. No other medical
advance has ever had the same impact in the clinical practise. The fungus Penicillium …

Modular synthetic biology toolkit for filamentous fungi

L Mózsik, C Pohl, V Meyer, RAL Bovenberg… - ACS Synthetic …, 2021 - ACS Publications
Filamentous fungi are highly productive cell factories, often used in industry for the
production of enzymes and small bioactive compounds. Recent years have seen an …

Transcriptional activation of biosynthetic gene clusters in filamentous fungi

L Mózsik, R Iacovelli, RAL Bovenberg… - … in Bioengineering and …, 2022 - frontiersin.org
Filamentous fungi are highly productive cell factories, many of which are industrial
producers of enzymes, organic acids, and secondary metabolites. The increasing number of …

Fungal BGCs for production of secondary metabolites: main types, central roles in strain improvement, and regulation according to the piano principle

AA Zhgun - International Journal of Molecular Sciences, 2023 - mdpi.com
Filamentous fungi are one of the most important producers of secondary metabolites. Some
of them can have a toxic effect on the human body, leading to diseases. On the other hand …

Myco-synthesized molluscicidal and larvicidal selenium nanoparticles: A new strategy to control Biomphalaria alexandrina snails and larvae of Schistosoma mansoni …

MY Morad, H El-Sayed, AA Elhenawy, SM Korany… - Journal of Fungi, 2022 - mdpi.com
Schistosomiasis is a tropical disease with socioeconomic problems. The goal of this study
was to determine the influence of myco-synthesized nano-selenium (SeNPs) as a …

Construction of an expression platform for fungal secondary metabolite biosynthesis in Penicillium crustosum

J Zhou, X Chen, SM Li - Applied Microbiology and Biotechnology, 2024 - Springer
Filamentous fungi are prolific producers of bioactive natural products and play a vital role in
drug discovery. Yet, their potential cannot be fully exploited since many biosynthetic genes …