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Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …
[HTML][HTML] Develo** fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity
X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …
notably for therapeutic agent development. Genome sequencing revealed that the number …
The Potency of Fungal-Fabricated Selenium Nanoparticles to Improve the Growth Performance of Helianthus annuus L. and Control of Cutworm Agrotis ipsilon
The application of green nanotechnology in agriculture has been receiving substantial
attention, especially in the development of new nano-fertilizers and nano-insecticides …
attention, especially in the development of new nano-fertilizers and nano-insecticides …
Advances and challenges in CRISPR/Cas-based fungal genome engineering for secondary metabolite production: A review
D Wang, S **, Q Lu, Y Chen - Journal of Fungi, 2023 - mdpi.com
Fungi represent an important source of bioactive secondary metabolites (SMs), which have
wide applications in many fields, including medicine, agriculture, human health, and many …
wide applications in many fields, including medicine, agriculture, human health, and many …
Penicillium chrysogenum, a Vintage Model with a Cutting-Edge Profile in Biotechnology
The discovery of penicillin entailed a decisive breakthrough in medicine. No other medical
advance has ever had the same impact in the clinical practise. The fungus Penicillium …
advance has ever had the same impact in the clinical practise. The fungus Penicillium …
Modular synthetic biology toolkit for filamentous fungi
Filamentous fungi are highly productive cell factories, often used in industry for the
production of enzymes and small bioactive compounds. Recent years have seen an …
production of enzymes and small bioactive compounds. Recent years have seen an …
Transcriptional activation of biosynthetic gene clusters in filamentous fungi
Filamentous fungi are highly productive cell factories, many of which are industrial
producers of enzymes, organic acids, and secondary metabolites. The increasing number of …
producers of enzymes, organic acids, and secondary metabolites. The increasing number of …
Fungal BGCs for production of secondary metabolites: main types, central roles in strain improvement, and regulation according to the piano principle
AA Zhgun - International Journal of Molecular Sciences, 2023 - mdpi.com
Filamentous fungi are one of the most important producers of secondary metabolites. Some
of them can have a toxic effect on the human body, leading to diseases. On the other hand …
of them can have a toxic effect on the human body, leading to diseases. On the other hand …
Myco-synthesized molluscicidal and larvicidal selenium nanoparticles: A new strategy to control Biomphalaria alexandrina snails and larvae of Schistosoma mansoni …
Schistosomiasis is a tropical disease with socioeconomic problems. The goal of this study
was to determine the influence of myco-synthesized nano-selenium (SeNPs) as a …
was to determine the influence of myco-synthesized nano-selenium (SeNPs) as a …
Construction of an expression platform for fungal secondary metabolite biosynthesis in Penicillium crustosum
J Zhou, X Chen, SM Li - Applied Microbiology and Biotechnology, 2024 - Springer
Filamentous fungi are prolific producers of bioactive natural products and play a vital role in
drug discovery. Yet, their potential cannot be fully exploited since many biosynthetic genes …
drug discovery. Yet, their potential cannot be fully exploited since many biosynthetic genes …