The human intestinal microbiome substantially affects human health and resistance to
infections in its dynamic composition and varying release of microbial-derived metabolites …

Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

An increased intestinal permeability has been described in various gastrointestinal and non-
gastrointestinal disorders. Nevertheless, the concept and definition of intestinal permeability …

The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

Introduction: The gastrointestinal mucosa constitutes a critical barrier where millions of
microbes and environmental antigens come in close contact with the host immune system …

NAFLD is currently the main cause of chronic liver disease in developed countries, and the
number of NAFLD patients is growing worldwide. NAFLD often has similar symptoms to …

Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in more
than 5% of hepatocytes in the absence of excessive alcohol consumption and other …

Inflammation and hepatocyte injury and death are the hallmarks of nonalcoholic
steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease (NAFLD) …

Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic
fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early …

Background: Increased intestinal permeability due to barrier dysfunction is supposed to
cause microbial translocation which may induce low-grade inflammation in various …