Ki67 is a promising molecular target in the diagnosis of cancer
LT Li, G Jiang, Q Chen… - Molecular medicine …, 2015 - spandidos-publications.com
The expression of Ki67 is strongly associated with tumor cell proliferation and growth, and is
widely used in routine pathological investigation as a proliferation marker. The nuclear …
widely used in routine pathological investigation as a proliferation marker. The nuclear …
Functional nucleic acid biosensors utilizing rolling circle amplification
Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding
increasing use as molecular recognition elements for point-of-care (POC) assays and …
increasing use as molecular recognition elements for point-of-care (POC) assays and …
Designing chemically modified oligonucleotides for targeted gene silencing
GF Deleavey, MJ Damha - Chemistry & biology, 2012 - cell.com
Oligonucleotides (ONs), and their chemically modified mimics, are now routinely used in the
laboratory as a means to control the expression of fundamentally interesting or …
laboratory as a means to control the expression of fundamentally interesting or …
Triplex DNA structures
A DNA triplex is formed when pyrimidine or purine bases occupy the major groove of the
DNA double Helix forming Hoogsteen pairs with purines of the Watson-Crick basepairs …
DNA double Helix forming Hoogsteen pairs with purines of the Watson-Crick basepairs …
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and
RNA strands more strongly than a corresponding DNA strand, and exhibit increased …
RNA strands more strongly than a corresponding DNA strand, and exhibit increased …
Peptide nucleic acids having amino acid side chains
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and
RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit …
RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit …
Hydrogel-coated microneedle arrays for minimally invasive sampling and sensing of specific circulating nucleic acids from skin interstitial fluid
Minimally invasive technologies that can sample and detect cell-free nucleic acid
biomarkers from liquid biopsies have recently emerged as clinically useful for early …
biomarkers from liquid biopsies have recently emerged as clinically useful for early …
Chemistry can make strict and fuzzy controls for bio-systems: DNA nanoarchitectonics and cell-macromolecular nanoarchitectonics
M Komiyama, K Yoshimoto, M Sisido… - Bulletin of the Chemical …, 2017 - academic.oup.com
In this review, we introduce two kinds of bio-related nanoarchitectonics, DNA
nanoarchitectonics and cell-macromolecular nanoarchitectonics, both of which are basically …
nanoarchitectonics and cell-macromolecular nanoarchitectonics, both of which are basically …
Cell penetrating peptides, novel vectors for gene therapy
Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first
identified~ 25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring …
identified~ 25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring …
[HTML][HTML] Antisense oligonucleotides in therapy for neurodegenerative disorders
MM Evers, LJA Toonen… - Advanced drug delivery …, 2015 - Elsevier
Antisense oligonucleotides are synthetic single stranded strings of nucleic acids that bind to
RNA and thereby alter or reduce expression of the target RNA. They can not only reduce …
RNA and thereby alter or reduce expression of the target RNA. They can not only reduce …