Beyond the paradigm: Combining mass spectrometry and nuclear magnetic resonance for metabolomics

DD Marshall, R Powers - Progress in nuclear magnetic resonance …, 2017 - Elsevier
Metabolomics is undergoing tremendous growth and is being employed to solve a diversity
of biological problems from environmental issues to the identification of biomarkers for …

HILIC‐MS for metabolomics: An attractive and complementary approach to RPLC‐MS

DQ Tang, L Zou, XX Yin, CN Ong - Mass spectrometry reviews, 2016 - Wiley Online Library
Hydrophilic interaction chromatography (HILIC) is an emerging separation mode of liquid
chromatography (LC). Using highly hydrophilic stationary phases capable of retaining …

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

T Downing, H Imamura, S Decuypere, TG Clark… - Genome …, 2011 - genome.cshlp.org
Visceral leishmaniasis is a potentially fatal disease endemic to large parts of Asia and Africa,
primarily caused by the protozoan parasite Leishmania donovani. Here, we report a high …

Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective

O Prakash Singh, B Singh, J Chakravarty… - Infectious diseases of …, 2016 - mednexus.org
Visceral leishmaniasis (VL) is a serious parasitic disease causing considerable mortality
and major disability in the Indian subcontinent. It is most neglected tropical disease …

PeakML/mzMatch: a file format, Java library, R library, and tool-chain for mass spectrometry data analysis

RA Scheltema, A Jankevics, RC Jansen… - Analytical …, 2011 - ACS Publications
The recent proliferation of high-resolution mass spectrometers has generated a wealth of
new data analysis methods. However, flexible integration of these methods into …

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

A Trochine, DJ Creek, P Faral-Tello… - PLoS neglected …, 2014 - journals.plos.org
Background The first line treatment for Chagas disease, a neglected tropical disease caused
by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole …

[HTML][HTML] Molecular Mechanisms of Drug Resistance in Leishmania spp.

MJ Moncada-Diaz, CC Rodríguez-Almonacid… - Pathogens, 2024 - mdpi.com
The protozoan parasite Leishmania causes leishmaniasis, a neglected tropical disease, that
disproportionately affects underdeveloped countries. This disease has major health …

Evaluation of normalization methods to pave the way towards large-scale LC-MS-based metabolomics profiling experiments

BA Ejigu, D Valkenborg, G Baggerman… - Omics: a journal of …, 2013 - liebertpub.com
Combining liquid chromatography-mass spectrometry (LC-MS)-based metabolomics
experiments that were collected over a long period of time remains problematic due to …

[HTML][HTML] “Omic” approaches to bacteria and antibiotic resistance identification

D Janiszewska, M Szultka-Młyńska… - International journal of …, 2022 - mdpi.com
The quick and accurate identification of microorganisms and the study of resistance to
antibiotics is crucial in the economic and industrial fields along with medicine. One of the …

Evaluation of mobile phase characteristics on three zwitterionic columns in hydrophilic interaction liquid chromatography mode for liquid chromatography-high …

R Zhang, DG Watson, L Wang, GD Westrop… - … of Chromatography A, 2014 - Elsevier
It has been reported that HILIC column chemistry has a great effect on the number of
detected metabolites in LC–HRMS-based untargeted metabolite profiling studies. However …