Neuroinflammation and perioperative neurocognitive disorders

S Subramaniyan, N Terrando - Anesthesia & Analgesia, 2019‏ - journals.lww.com
Neuroinflammation has become a key hallmark of neurological complications including
perioperative pathologies such as postoperative delirium and longer-lasting postoperative …

[HTML][HTML] The potential mechanism of postoperative cognitive dysfunction in older people

X Lin, Y Chen, P Zhang, G Chen, Y Zhou, X Yu - Experimental gerontology, 2020‏ - Elsevier
Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …

Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies

DR Skvarc, M Berk, LK Byrne, OM Dean, S Dodd… - Neuroscience & …, 2018‏ - Elsevier
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …

Neuroinflammation in the normal aging hippocampus

RM Barrientos, MM Kitt, LR Watkins, SF Maier - Neuroscience, 2015‏ - Elsevier
A consequence of normal aging is a greater susceptibility to memory impairments following
an immune challenge such as infection, surgery, or traumatic brain injury. The …

Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment

Z Wang, S Meng, L Cao, Y Chen, Z Zuo… - Journal of …, 2018‏ - Springer
Background Elderly patients are more likely to suffer from postoperative cognitive
dysfunction (POCD) after surgery and anesthesia. Except for declined organ function, the …

Research progress on the role of inflammatory mechanisms in the development of postoperative cognitive dysfunction

X Tan, LL Qiu, J Sun - BioMed research international, 2021‏ - Wiley Online Library
Postoperative cognitive dysfunction (POCD), as one of the common postoperative
complications, mainly occurs after surgery and anesthesia, especially in the elderly. It refers …

The potential role of the NLRP3 inflammasome activation as a link between mitochondria ROS generation and neuroinflammation in postoperative cognitive …

P Wei, F Yang, Q Zheng, W Tang, J Li - Frontiers in Cellular …, 2019‏ - frontiersin.org
Postoperative cognitive dysfunction (POCD) is commonly observed in perioperative care
following major surgery and general anesthesia in elderly individuals. No preventive or …

Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders

C Cheng, H Wan, P Cong, X Huang, T Wu… - Journal of …, 2022‏ - Springer
Perioperative neurocognitive disorders (PND) is a common postoperative complication
associated with regional or general anesthesia and surgery. Growing evidence in both …

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation

AL Luo, J Yan, XL Tang, YL Zhao, BY Zhou… - Inflammopharmacology, 2019‏ - Springer
The aging population is burgeoning globally and this trend presents great challenges to the
current healthcare system as the growing number of aged individuals receives procedures …

Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models

W Wang, LS Zhang, AK Zinsmaier, G Patterson… - PLoS …, 2019‏ - journals.plos.org
Hearing loss is a major risk factor for tinnitus, hyperacusis, and central auditory processing
disorder. Although recent studies indicate that hearing loss causes neuroinflammation in the …