Rationally designed multi-target drugs (also termed multimodal drugs, network therapeutics,
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …

Epilepsy is a common disease of the nervous system characterized by transient brain
dysfunction caused by an abnormal electrical discharge from the brain neurons. The …

In this study, the immobilization of sulfaguanidine-SA on the surface of FeAl2O4 (hercynite)
MNPs (magnetic nanoparticles) as a novel acid nanocatalyst has been successfully reported …

Voltage‐gated sodium channels (VGSCs/Navs), which control the flow of Na+ and affect the
generation of action potentials (APs), have been regarded as essential targets for many …

Despite the constant development of new antiepileptic drugs (AEDs), more than 30% of
patients develop refractory epilepsy (RE) characterized by a multidrug-resistant (MDR) …

The superfamily of P-loop channels includes potassium, sodium, and calcium channels, as
well as TRP channels and ionotropic glutamate receptors. A rapidly increasing number of …

The incidence rate of nervous system diseases has increased in recent years. Nerve injury
or neurodegenerative diseases usually cause neuronal loss and neuronal circuit damage …

In order to expand the arsenal of biologically active substances of anticonvulsive action by
the interaction of 2-(2, 4-dioxo-1, 4-dihydroquinazolin-3 (2H)-yl) acetic acid with the …

Propylparaben, a commonly used antimicrobial preservative, has been reported as an
anticonvulsant agent targeting neuronal Na+ channels (Na V). However, the specific …

The superfamily of membrane proteins known as P-loop channels encompasses potassium,
sodium, and calcium channels, as well as TRP channels and ionotropic glutamate receptors …