[HTML][HTML] Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Y Ju, Y Hu, P Yang, X **e, B Fang - Materials Today Bio, 2023 - Elsevier
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale vesicles
secreted by cells that play important biological roles. Mesenchymal stem cells are a class of …

Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment

B Lv, L Lu, L Hu, P Cheng, Y Hu, X **e, G Dai… - …, 2023 - pmc.ncbi.nlm.nih.gov
Increasing data reveals that gelatin that has been methacrylated is involved in a variety of
physiologic processes that are important for therapeutic interventions. Gelatin methacryloyl …

Biomimetic natural biopolymer‐based wet‐tissue adhesive for tough adhesion, seamless sealed, emergency/nonpressing hemostasis, and promoted wound healing

W Yang, X Kang, X Gao, Y Zhuang… - Advanced Functional …, 2023 - Wiley Online Library
Bioadhesives have been used in clinics among the most prospective alternatives to sutures
and staples for wound sealing and repairing; however, they generally have inadequate …

Engineering extracellular vesicles as delivery systems in therapeutic applications

L Wang, D Wang, Z Ye, J Xu - Advanced Science, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into
the extracellular environment. Recent studies have shown that EVs serve as “messengers” …

Robust and multifunctional nanoparticles assembled from natural polyphenols and metformin for efficient spinal cord regeneration

T Yuan, T Wang, J Zhang, P Liu, J Xu, Z Gu, J Xu, Y Li - ACS nano, 2023 - ACS Publications
The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex
pathophysiological microenvironments at the injury site and the limited regenerative …

Designing hydrogels for immunomodulation in cancer therapy and regenerative medicine

Z Zhang, C He, X Chen - Advanced Materials, 2024 - Wiley Online Library
The immune system not only acts as a defense against pathogen and cancer cells, but also
plays an important role in homeostasis and tissue regeneration. Targeting immune systems …

Hyaluronan-based hydrogel integrating exosomes for traumatic brain injury repair by promoting angiogenesis and neurogenesis

X Liu, C Wu, Y Zhang, S Chen, J Ding, Z Chen… - Carbohydrate …, 2023 - Elsevier
With wide clinical demands, therapies for traumatic brain injury (TBI) are far from satisfactory.
Combining the merits of stem cells but avoiding the risk of immunologic rejection, bone …

Injectable intrinsic photothermal hydrogel bioadhesive with on‐demand removability for wound closure and mrsa‐infected wound healing

X Kang, P Guan, C **ao, C Liu, Y Guan… - Advanced …, 2023 - Wiley Online Library
Photothermal hydrogel adhesives have yielded promising results for wound closure and
infected wound treatment in recent years. However, photothermal hydrogel bioadhesives …

Biotin–avidin system-based delivery enhances the therapeutic performance of MSC-derived exosomes

D Deng, X Li, JJ Zhang, Y Yin, Y Tian, D Gan, R Wu… - ACS …, 2023 - ACS Publications
Exosomes (EXs) shed by mesenchymal stem cells (MSCs) are potent therapeutic agents
that promote wound healing and regeneration, but when used alone in vivo, their …

A Redox Homeostasis Modulatory Hydrogel with GLRX3+ Extracellular Vesicles Attenuates Disc Degeneration by Suppressing Nucleus Pulposus Cell Senescence

C Liu, L Fan, M Guan, Q Zheng, J **, X Kang, Z Gao… - Acs Nano, 2023 - ACS Publications
Characterized by nucleus pulposus (NP) cell senescence and extracellular matrix (ECM)
degradation, disc degeneration is a common pathology for various degenerative spinal …