Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation
Y Wan, G Fang, H Chen, X Deng, Z Tang - European Journal of Medicinal …, 2021 - Elsevier
Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer
agents are major challenges for cancer treatment, which energizes medicinal chemists to …
agents are major challenges for cancer treatment, which energizes medicinal chemists to …
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
Novel 1, 2, 4-oxadiazole derivatives in drug discovery
Five-membered 1, 2, 4-oxadiazole heterocyclic ring has received considerable attention
because of its unique bioisosteric properties and an unusually wide spectrum of biological …
because of its unique bioisosteric properties and an unusually wide spectrum of biological …
Carbonic anhydrase IX: A tumor acidification switch in heterogeneity and chemokine regulation
The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …
π–π noncovalent interaction involving 1, 2, 4-and 1, 3, 4-oxadiazole systems: The combined experimental, theoretical, and database study
A series of N-pyridyl ureas bearing 1, 2, 4-(1a, 2a, and 3a) and 1, 3, 4-oxadiazole moiety
(1b, 2b, 3b) was prepared and characterized by HRMS, 1H and 13C NMR spectroscopy, as …
(1b, 2b, 3b) was prepared and characterized by HRMS, 1H and 13C NMR spectroscopy, as …
3-Methylthiazolo [3, 2-a] benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis …
Herein we describe design and synthesis of different series of novel small molecules
featuring 3-methylthiazolo [3, 2-a] benzimidazole moiety (as a tail) connected to the zinc …
featuring 3-methylthiazolo [3, 2-a] benzimidazole moiety (as a tail) connected to the zinc …
Groundbreaking anticancer activity of highly diversified oxadiazole scaffolds
A Benassi, F Doria, V Pirota - International journal of molecular sciences, 2020 - mdpi.com
Nowadays, an increasing number of heterocyclic-based drugs found application in
medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles …
medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles …
1, 3-Dipolar cycloaddition, HPLC enantioseparation, and docking studies of saccharin/isoxazole and saccharin/isoxazoline derivatives as selective carbonic …
Two series of saccharin/isoxazole and saccharin/isoxazoline hybrids were synthesized by 1,
3-dipolar cycloaddition. The new compounds showed to be endowed with potent and …
3-dipolar cycloaddition. The new compounds showed to be endowed with potent and …
Application of nitriles on the synthesis of 1, 3-oxazoles, 2-oxazolines, and oxadiazoles: An update from 2014 to 2021
The importance of 5-membered azaheterocycles is well established, especially in the
medicinal chemistry field, as these nuclei are present in many marketed top-selling drugs …
medicinal chemistry field, as these nuclei are present in many marketed top-selling drugs …
Room temperature synthesis of bioactive 1, 2, 4-oxadiazoles
1, 2, 4-Oxadiazole is an essential motif in drug discovery represented in many experimental,
investigational, and marketed drugs. This review covers synthetic methods that allow the …
investigational, and marketed drugs. This review covers synthetic methods that allow the …