The yeast cell wall is a strong, but elastic, structure that is essential not only for the
maintenance of cell shape and integrity, but also for progression through the cell cycle …

Proteomics, the large-scale analysis of proteins, will contribute greatly to our understanding
of gene function in the post-genomic era. Proteomics can be divided into three main …

Existing computational pipelines for quantitative analysis of high‐content microscopy data
rely on traditional machine learning approaches that fail to accurately classify more than a …

Breast cancer patients with the same stage of disease can have markedly different treatment
responses and overall outcome. The strongest predictors for metastases (for example, lymph …

Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …

This book unifies and extends latent variable models, including multilevel or generalized
linear mixed models, longitudinal or panel models, item response or factor models, latent …

Motivation: DNA microarray experiments generating thousands of gene expression
measurements, are being used to gather information from tissue and cell samples regarding …

The ability to adapt to altered availability of free water is a fundamental property of living
cells. The principles underlying osmoadaptation are well conserved. The yeast …

We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as …

G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to
respond to specific cues in their environment. However, the relationship between stimulus …