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Unravelling the mechanisms of PFOS toxicity by combining morphological and transcriptomic analyses in zebrafish embryos
Exposure to PFOS (perfluorooctanesulfonate) has been related to toxic effects on lipid
metabolism, immunological response, and different endocrine systems. We present here a …
metabolism, immunological response, and different endocrine systems. We present here a …
Transcriptomic effects of tributyltin (TBT) in zebrafish eleutheroembryos. A functional benchmark dose analysis
Exposure to the antifouling tributyltin (TBT) has been related to imposex in mollusks and to
obesogenicity, adipogenesis and masculinization in fish. To understand the underlying …
obesogenicity, adipogenesis and masculinization in fish. To understand the underlying …
ALASCA: an R package for longitudinal and cross-sectional analysis of multivariate data by ASCA-based methods
AH Jarmund, TS Madssen… - Frontiers in Molecular …, 2022 - frontiersin.org
The increasing availability of multivariate data within biomedical research calls for
appropriate statistical methods that can describe and model complex relationships between …
appropriate statistical methods that can describe and model complex relationships between …
limpca: An R package for the linear modeling of high‐dimensional designed data based on ASCA/APCA family of methods
M Thiel, N Benaiche, M Martin… - Journal of …, 2023 - Wiley Online Library
Many modern analytical methods are used to analyze samples issued from an experimental
design, for example, in medical, biological, chemical, or agronomic fields. Those methods …
design, for example, in medical, biological, chemical, or agronomic fields. Those methods …
Dose-dependent transcriptomic responses of zebrafish eleutheroembryos to Bisphenol A
Despite the abundant literature on the adverse effects of Bisphenol A (BPA) as endocrine
disruptor, its toxicity mechanisms are still poorly understood. We present here a study of its …
disruptor, its toxicity mechanisms are still poorly understood. We present here a study of its …
Promises and challenges of eco-physiological genomics in the field: tests of drought responses in switchgrass
Identifying the physiological and genetic basis of stress tolerance in plants has proven to be
critical to understanding adaptation in both agricultural and natural systems. However, many …
critical to understanding adaptation in both agricultural and natural systems. However, many …
Invasive micropapillary carcinoma of the breast overexpresses MUC4 and is associated with poor outcome to adjuvant trastuzumab in HER2-positive breast cancer
Background Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor
variant that occurs with low frequency characterized by an inside-out formation of tumor …
variant that occurs with low frequency characterized by an inside-out formation of tumor …
[HTML][HTML] A novel multivariate curve resolution based strategy for multi-omic integration of toxicological data
A Menéndez-Pedriza, L Navarro-Martín… - … and Intelligent Laboratory …, 2023 - Elsevier
Multi-omics has become a current subject of research in computational bioinformatics and
chemometrics to trigger a more accurate understanding of biological processes. The …
chemometrics to trigger a more accurate understanding of biological processes. The …
Effects of Single and Combined Low Concentrations of Neuroactive Drugs on Daphnia magna Reproduction and Transcriptomic Responses
Assessing the risk of neuroactive pharmaceuticals in the environment requires an
understanding of their joint effects at low concentrations across species. Here, we assessed …
understanding of their joint effects at low concentrations across species. Here, we assessed …
Combined effects of temperature and light intensity on growth, metabolome and ovatoxin content of a Mediterranean Ostreopsis cf. ovata strain
Ostreopsis cf. ovata is a benthic and ovatoxin-producing dinoflagellate proliferating yearly
along the Mediterranean coasts where blooms have been related to human illness and …
along the Mediterranean coasts where blooms have been related to human illness and …