Unravelling the mechanisms of PFOS toxicity by combining morphological and transcriptomic analyses in zebrafish embryos

R Martínez, L Navarro-Martín, C Luccarelli… - Science of the Total …, 2019 - Elsevier
Exposure to PFOS (perfluorooctanesulfonate) has been related to toxic effects on lipid
metabolism, immunological response, and different endocrine systems. We present here a …

Transcriptomic effects of tributyltin (TBT) in zebrafish eleutheroembryos. A functional benchmark dose analysis

R Martínez, AE Codina, C Barata, R Tauler… - Journal of Hazardous …, 2020 - Elsevier
Exposure to the antifouling tributyltin (TBT) has been related to imposex in mollusks and to
obesogenicity, adipogenesis and masculinization in fish. To understand the underlying …

ALASCA: an R package for longitudinal and cross-sectional analysis of multivariate data by ASCA-based methods

AH Jarmund, TS Madssen… - Frontiers in Molecular …, 2022 - frontiersin.org
The increasing availability of multivariate data within biomedical research calls for
appropriate statistical methods that can describe and model complex relationships between …

limpca: An R package for the linear modeling of high‐dimensional designed data based on ASCA/APCA family of methods

M Thiel, N Benaiche, M Martin… - Journal of …, 2023 - Wiley Online Library
Many modern analytical methods are used to analyze samples issued from an experimental
design, for example, in medical, biological, chemical, or agronomic fields. Those methods …

Dose-dependent transcriptomic responses of zebrafish eleutheroembryos to Bisphenol A

R Martinez, A Esteve-Codina, L Herrero-Nogareda… - Environmental …, 2018 - Elsevier
Despite the abundant literature on the adverse effects of Bisphenol A (BPA) as endocrine
disruptor, its toxicity mechanisms are still poorly understood. We present here a study of its …

Promises and challenges of eco-physiological genomics in the field: tests of drought responses in switchgrass

JT Lovell, EV Shakirov, S Schwartz, DB Lowry… - Plant …, 2016 - academic.oup.com
Identifying the physiological and genetic basis of stress tolerance in plants has proven to be
critical to understanding adaptation in both agricultural and natural systems. However, many …

[HTML][HTML] A novel multivariate curve resolution based strategy for multi-omic integration of toxicological data

A Menéndez-Pedriza, L Navarro-Martín… - … and Intelligent Laboratory …, 2023 - Elsevier
Multi-omics has become a current subject of research in computational bioinformatics and
chemometrics to trigger a more accurate understanding of biological processes. The …

Effects of Single and Combined Low Concentrations of Neuroactive Drugs on Daphnia magna Reproduction and Transcriptomic Responses

I Fuertes, B Campos, C Rivetti, B Pina… - … Science & Technology, 2019 - ACS Publications
Assessing the risk of neuroactive pharmaceuticals in the environment requires an
understanding of their joint effects at low concentrations across species. Here, we assessed …

Combined effects of temperature and light intensity on growth, metabolome and ovatoxin content of a Mediterranean Ostreopsis cf. ovata strain

MP Gémin, S Bertrand, V Séchet, Z Amzil, D Réveillon - Harmful Algae, 2021 - Elsevier
Ostreopsis cf. ovata is a benthic and ovatoxin-producing dinoflagellate proliferating yearly
along the Mediterranean coasts where blooms have been related to human illness and …