Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes

M Arabpour, A Saghazadeh, N Rezaei - International …, 2021 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent cells beneficial in regenerative medicine
and tissue repair. The therapeutic potential of MSCs for inflammatory diseases and …

Regulatory microRNAs in brown, brite and white adipose tissue

S Gharanei, K Shabir, JE Brown, MO Weickert… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) constitute a class of short noncoding RNAs which regulate gene
expression by targeting messenger RNA, inducing translational repression and messenger …

[HTML][HTML] Adipocyte-derived exosomal MiR-27a induces insulin resistance in skeletal muscle through repression of PPARγ

Y Yu, H Du, S Wei, L Feng, J Li, F Yao, M Zhang… - Theranostics, 2018 - ncbi.nlm.nih.gov
The mechanism by which adipocyte-derived endocrine factors promote insulin resistance in
skeletal muscle are not fully understood. MiR-27a is highly expressed in sera of obese …

[HTML][HTML] Mesenchymal stem cell–derived extracellular vesicles alleviate acute lung injury via transfer of miR-27a-3p

J Wang, R Huang, Q Xu, G Zheng, G Qiu… - Critical Care …, 2020 - journals.lww.com
Objectives: The goal of this study was to determine the role of microRNA transfer in
mediating the effects of mesenchymal stem cell–derived extracellular vesicles in acute lung …

MicroRNA: dynamic regulators of macrophage polarization and plasticity

JB Self-Fordham, AR Naqvi, JR Uttamani… - Frontiers in …, 2017 - frontiersin.org
The ability of a healthy immune system to clear the plethora of antigens it encounters
incessantly relies on the enormous plasticity displayed by the comprising cell types …

miR-221-3p drives the shift of M2-macrophages to a pro-inflammatory function by suppressing JAK3/STAT3 activation

L Quero, AN Tiaden, E Hanser, J Roux, A Laski… - Frontiers in …, 2020 - frontiersin.org
Objectives: Macrophages are conventionally classified as pro-inflammatory (M1) and anti-
inflammatory (M2) functional types. There is evidence for a predominance of macrophages …

The diverse roles of microRNAs at the host–virus interface

A Bernier, SM Sagan - Viruses, 2018 - mdpi.com
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-
transcriptional level. Through this activity, they are implicated in almost every cellular …

microRNAs in human adipose tissue physiology and dysfunction

A Kurylowicz - Cells, 2021 - mdpi.com
In recent years, there has been a large amount of evidence on the role of microRNA
(miRNA) in regulating adipose tissue physiology. Indeed, miRNAs control critical steps in …

[HTML][HTML] Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature

K Khalaj, JE Miller, H Lingegowda, AT Fazleabas… - JCI insight, 2019 - ncbi.nlm.nih.gov
With multifactorial etiologies, combined with disease heterogeneity and a lack of suitable
diagnostic markers and therapy, endometriosis remains a major reproductive health …

A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression

S Ma, M Liu, Z Xu, Y Li, H Guo, Y Ge, Y Liu… - …, 2015 - pmc.ncbi.nlm.nih.gov
In response to microenvironmental signals, macrophages undergo different types of
activation, including the “classic” pro-inflammatory phenotype (also called M1) and the …