Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …

Aberrant regulation of myocardial force production represents an early biomechanical defect
associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly …

Acto-myosin cross-bridge kinetics are important for beat-to-beat regulation of cardiac
contractility; however, physiological and pathophysiological mechanisms for regulation of …

Familial dilated cardiomyopathy (DCM), clinically characterized by enlargement and
dysfunction of one or both ventricles of the heart, can be caused by variants in sarcomeric …

Investigations of cardiomyopathy mutations in Ca 2+ regulatory proteins troponin and
tropomyosin provide crucial information about cardiac disease mechanisms, and also …

The dynamic oscillations of tropomyosin molecules in the azimuthal direction over the
surface of the actin filament during thin filament activation are studied here from an energy …

Cardiac muscle contraction is regulated via Ca2+ exchange with the hetero-trimeric troponin
complex located on the thin filament. Binding of Ca2+ to cardiac troponin C, a Ca2+ sensing …

During the excitation–contraction coupling of the heart, sarcomeres are activated via thin
filament structural changes (ie, from the “off” state to the “on” state) in response to a release …

Abstract We use Brownian-Langevin dynamics principles to derive a coarse-graining
multiscale myofilament model that can describe the thin-filament activation process during …

Cardiac troponin C (cTnC) is a key effector in cardiac muscle excitation-contraction coupling
as the Ca2+ sensing subunit responsible for controlling contraction. In this study, we …