Eukaryotic elongation factor 1A (eEF1A) is an essential and highly conserved protein
involved in diverse cellular processes, including translation, cytoskeleton organisation …

Synaptic plasticity involves structural modifications in dendritic spines that are modulated by
local protein synthesis and actin remodeling. Here, we investigated the molecular …

Eukaryotic elongation factor 1A1 (EEF1A1) is canonically involved in protein synthesis, but
also has non-canonical functions in diverse cellular processes. Previously, we identified …

Abstract Background Elongation factor 1 A (EF1A), an essential regulator for protein
synthesis, has been reported to participate in abiotic stress responses and environmental …

Heterozygous de novo variants in the eukaryotic elongation factor EEF1A2 have previously
been described in association with intellectual disability and epilepsy but never functionally …

All vertebrate species express two independently-encoded forms of translation elongation
factor eEF1A. In humans and mice eEF1A1 and eEF1A2 are 92% identical at the amino acid …

Eukaryotic elongation factor eEF1A transits between the GTP-and GDP-bound
conformations during the ribosomal polypeptide chain elongation. eEF1A* GTP establishes …

Genome-wide association studies have identified two loci, SNCA and the microtubule (MT)-
associated protein tau, as common risk factors for Parkinson's disease (PD). Specifically, α …

P21 activated kinase 4 (PAK4), as an effector of Cdc42, playing important roles in regulating
the processes of cytoskeleton organization. PAK4 has been considered to be an oncogenic …

We identified eukaryotic translation elongation factor 1A (eEF1A) Raf-mediated
phosphorylation sites and defined their role in the regulation of eEF1A half-life and of …