The endothelium, a key actor in organ development and hPSC-derived organoid vascularization
A Vargas-Valderrama, A Messina… - Journal of Biomedical …, 2020 - Springer
Over the last 4 decades, cell culture techniques have evolved towards the creation of in vitro
multicellular entities that incorporate the three-dimensional complexity of in vivo tissues and …
multicellular entities that incorporate the three-dimensional complexity of in vivo tissues and …
Current perspective: 3D spheroid models utilizing human-based cells for investigating metabolism-dependent drug-induced liver injury
CR Cox, S Lynch, C Goldring… - Frontiers in medical …, 2020 - frontiersin.org
Drug-induced liver injury (DILI) remains a leading cause for the withdrawal of approved
drugs. This has significant financial implications for pharmaceutical companies, places …
drugs. This has significant financial implications for pharmaceutical companies, places …
Engineering neurovascular organoids with 3D printed microfluidic chips
The generation of tissue and organs requires close interaction with vasculature from the
earliest moments of embryonic development. Tissue-specific organoids derived from …
earliest moments of embryonic development. Tissue-specific organoids derived from …
[HTML][HTML] A human liver organoid screening platform for DILI risk prediction
Background & Aims Drug-induced liver injury (DILI), both intrinsic and idiosyncratic, causes
frequent morbidity, mortality, clinical trial failures and post-approval withdrawal. This …
frequent morbidity, mortality, clinical trial failures and post-approval withdrawal. This …
3D bioprinting of liver spheroids derived from human induced pluripotent stem cells sustain liver function and viability in vitro
The liver is responsible for many metabolic, endocrine and exocrine functions.
Approximately 2 million deaths per year are associated with liver failure. Modern 3D …
Approximately 2 million deaths per year are associated with liver failure. Modern 3D …
Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling
Background The generation of liver organoids recapitulating parenchymal and non-
parenchymal cell interplay is essential for the precise in vitro modeling of liver diseases …
parenchymal cell interplay is essential for the precise in vitro modeling of liver diseases …
[HTML][HTML] Evolution of organoid technology: Lessons learnt in Co-Culture systems from developmental biology
In recent years, the development of 3D organoids has opened new avenues of investigation
into development, physiology, and regenerative medicine. Organoid formation and the …
into development, physiology, and regenerative medicine. Organoid formation and the …
Advancements in stem cell-derived hepatocyte-like cell models for hepatotoxicity testing
M **, X Yi, W Liao, Q Chen, W Yang, Y Li, S Li… - Stem cell research & …, 2021 - Springer
Drug-induced liver injury (DILI) is one of the leading causes of clinical trial failures and high
drug attrition rates. Currently, the commonly used hepatocyte models include primary human …
drug attrition rates. Currently, the commonly used hepatocyte models include primary human …
Do not keep it simple: recent advances in the generation of complex organoids
Abstract 3D cell culture models which closely resemble real human tissues are of high
interest for disease modelling, drug screening as well as a deeper understanding of human …
interest for disease modelling, drug screening as well as a deeper understanding of human …
Challenges for the applications of human pluripotent stem cell-derived liver organoids
The current organoid culture systems allow pluripotent and adult stem cells to self-organize
to form three-dimensional (3D) structures that provide a faithful recapitulation of the …
to form three-dimensional (3D) structures that provide a faithful recapitulation of the …