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Dietary polyphenols, Mediterranean diet, prediabetes, and type 2 diabetes: a narrative review of the evidence
Dietary polyphenols come mainly from plant‐based foods including fruits, vegetables, whole
grains, coffee, tea, and nuts. Polyphenols may influence glycemia and type 2 diabetes (T2D) …
grains, coffee, tea, and nuts. Polyphenols may influence glycemia and type 2 diabetes (T2D) …
Genetics of type 2 diabetes—pitfalls and possibilities
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …
genetic, epigenetic and environmental factors. While the major environmental factors, diet …
[HTML][HTML] RNA sequencing of single human islet cells reveals type 2 diabetes genes
Y ** and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
We performed fine map** of 39 established type 2 diabetes (T2D) loci in 27,206 cases
and 57,574 controls of European ancestry. We identified 49 distinct association signals at …
and 57,574 controls of European ancestry. We identified 49 distinct association signals at …
[HTML][HTML] The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities
M Yu, K Qin, J Fan, G Zhao, P Zhao, W Zeng, C Chen… - Genes & …, 2024 - Elsevier
The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …
Coupled network of the circadian clocks: a driving force of rhythmic physiology
The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …
beings, including humans, to anticipate and adapt to daily changes in their environment. In …
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Most signals detected by genome-wide association studies map to non-coding sequence
and their tissue-specific effects influence transcriptional regulation. However, key tissues …
and their tissue-specific effects influence transcriptional regulation. However, key tissues …
High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease
Aims/hypothesis Type 2 diabetes is highly polygenic and influenced by multiple biological
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk
Identification of the genes and processes mediating genetic association signals for complex
diseases represents a major challenge. As many of the genetic signals for type 2 diabetes …
diseases represents a major challenge. As many of the genetic signals for type 2 diabetes …