Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …

The mechanical properties of cells are important in tissue homeostasis and enable cell
growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties …

Metal ions play crucial roles in thermal stability and folding kinetics of nucleic acids. For ions
(especially multivalent ions) in the close vicinity of nucleic acid surface, interion correlations …

Variability characterizes the complexity of biological systems and is essential for their
function. Microtubules (MTs) play a role in structural integrity, cell motility, material transport …

Microtubules are hollow cylindrical structures that constitute one of the three major classes
of cytoskeletal filaments. On the mesoscopic length scale of a cell, their material properties …

Memory is attributed to strengthened synaptic connections among particular brain neurons,
yet synaptic membrane components are transient, whereas memories can endure. This …

Microtubule plus end binding proteins (+ TIPs) localize to the dynamic plus ends of
microtubules, where they stimulate microtubule growth and recruit signaling molecules …

Microtubule self-assembly is largely governed by the chemical kinetics and thermodynamics
of tubulin-tubulin interactions. An important aspect of microtubule assembly is that hydrolysis …

Alzheimer's disease (AD) is the most common form of dementia in the elderly. Hallmark AD
neuropathology includes extracellular amyloid plaques composed largely of the amyloid-β …

Proteins in the fibrous amyloid state are a major hallmark of neurodegenerative disease.
Understanding the multiple conformations, or polymorphs, of amyloid proteins at the …