[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …
Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents
Drug discovery relies on the knowledge of not only drugs and targets, but also the
comparative agents and targets. These include poor binders and non-binders for develo** …
comparative agents and targets. These include poor binders and non-binders for develo** …
Trials and tribulations of MicroRNA therapeutics
AA Seyhan - International Journal of Molecular Sciences, 2024 - mdpi.com
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …
particularly various cancer types, has generated significant interest in exploring their …
miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology
Abstract miRNet is an easy-to-use, web-based platform designed to help elucidate
microRNA (miRNA) functions by integrating users' data with existing knowledge via network …
microRNA (miRNA) functions by integrating users' data with existing knowledge via network …
DIANA-miRPath v4. 0: expanding target-based miRNA functional analysis in cell-type and tissue contexts
DIANA-miRPath is an online miRNA analysis platform harnessing predicted or
experimentally supported miRNA interactions towards the exploration of combined miRNA …
experimentally supported miRNA interactions towards the exploration of combined miRNA …
miRTargetLink 2.0—interactive miRNA target gene and target pathway networks
Which genes, gene sets or pathways are regulated by certain miRNAs? Which miRNAs
regulate a particular target gene or target pathway in a certain physiological context …
regulate a particular target gene or target pathway in a certain physiological context …
Transcriptional linkage analysis with in vivo AAV-Perturb-seq
The ever-growing compendium of genetic variants associated with human pathologies
demands new methods to study genotype–phenotype relationships in complex tissues in a …
demands new methods to study genotype–phenotype relationships in complex tissues in a …
Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases
There is a scarcity of studies on the interactions between heavy metals and non-alcoholic
fatty liver disease (NAFLD). Using a variety of statistical approaches, we investigated the …
fatty liver disease (NAFLD). Using a variety of statistical approaches, we investigated the …
Plasma miRNA profile at COVID-19 onset predicts severity status and mortality
A Fernández-Pato, A Virseda-Berdices… - Emerging microbes & …, 2022 - Taylor & Francis
Background MicroRNAs (miRNAs) have a crucial role in regulating immune response
against infectious diseases, showing changes early in disease onset and before the …
against infectious diseases, showing changes early in disease onset and before the …
Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved
Converging evidence demonstrates that microRNAs (miRNAs) play an important role in the
etiology of cognitive impairment. Thus, we aim to:(i) identify the molecular mechanisms of …
etiology of cognitive impairment. Thus, we aim to:(i) identify the molecular mechanisms of …