[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic

C Diener, A Keller, E Meese - Trends in Genetics, 2022 - cell.com
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …

Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents

Y Zhou, Y Zhang, X Lian, F Li, C Wang… - Nucleic acids …, 2022 - academic.oup.com
Drug discovery relies on the knowledge of not only drugs and targets, but also the
comparative agents and targets. These include poor binders and non-binders for develo** …

Trials and tribulations of MicroRNA therapeutics

AA Seyhan - International Journal of Molecular Sciences, 2024 - mdpi.com
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …

miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology

L Chang, G Zhou, O Soufan, J **a - Nucleic acids research, 2020 - academic.oup.com
Abstract miRNet is an easy-to-use, web-based platform designed to help elucidate
microRNA (miRNA) functions by integrating users' data with existing knowledge via network …

DIANA-miRPath v4. 0: expanding target-based miRNA functional analysis in cell-type and tissue contexts

S Tastsoglou, G Skoufos, M Miliotis… - Nucleic Acids …, 2023 - academic.oup.com
DIANA-miRPath is an online miRNA analysis platform harnessing predicted or
experimentally supported miRNA interactions towards the exploration of combined miRNA …

miRTargetLink 2.0—interactive miRNA target gene and target pathway networks

F Kern, E Aparicio-Puerta, Y Li, T Fehlmann… - Nucleic acids …, 2021 - academic.oup.com
Which genes, gene sets or pathways are regulated by certain miRNAs? Which miRNAs
regulate a particular target gene or target pathway in a certain physiological context …

Transcriptional linkage analysis with in vivo AAV-Perturb-seq

AJ Santinha, E Klingler, M Kuhn, R Farouni, S Lagler… - Nature, 2023 - nature.com
The ever-growing compendium of genetic variants associated with human pathologies
demands new methods to study genotype–phenotype relationships in complex tissues in a …

Cadmium, lead, and mercury mixtures interact with non-alcoholic fatty liver diseases

HD Nguyen, MS Kim - Environmental Pollution, 2022 - Elsevier
There is a scarcity of studies on the interactions between heavy metals and non-alcoholic
fatty liver disease (NAFLD). Using a variety of statistical approaches, we investigated the …

Plasma miRNA profile at COVID-19 onset predicts severity status and mortality

A Fernández-Pato, A Virseda-Berdices… - Emerging microbes & …, 2022 - Taylor & Francis
Background MicroRNAs (miRNAs) have a crucial role in regulating immune response
against infectious diseases, showing changes early in disease onset and before the …

Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved

HD Nguyen, MS Kim - Toxicology, 2022 - Elsevier
Converging evidence demonstrates that microRNAs (miRNAs) play an important role in the
etiology of cognitive impairment. Thus, we aim to:(i) identify the molecular mechanisms of …