Hypercholesterolemia and dyslipidemia are associated with an increased risk for many
cancer types and with poor outcomes in patients with established disease. Whereas the …

Pathogenesis roles of phospholipids (PLs) in nonalcoholic fatty liver disease (NAFLD)
remain incompletely understood. This study investigated the role of PLs in the progression of …

Background Altered lipid metabolism is an emerging hallmark of aggressive breast cancers.
The N-myc downstream regulated gene (NDRG1) gene plays a critical role in peripheral …

Lipotoxicity, an accumulation of intracellular lipid metabolites, has been proposed as an
important pathogenic mechanism contributing to kidney dysfunction in the context of …

Disordered lysosomal/autophagy pathways initiate and drive pancreatitis, but the underlying
mechanisms and links to disease pathology are poorly understood. Here, we show that the …

Triclosan is a promising candidate of fatty acid synthase (FASN) inhibitor by blocking FASN
activity, but its effect on FASN expression and the underling epigenetic mechanism remain …

Charcot-Marie-Tooth (CMT) Neuropathien stellen als häufigste erblich bedingte
neurologische Erkrankungen eine Gruppe genetisch heterogener, chronisch progredienter …

Abnormal levels of fatty acids in the blood are associated with a myriad of chronic diseases.
Lipotoxicity contributes to kidney deterioration through cellular dysfunction and apoptosis in …