Transformation of biopharmaceutical manufacturing through single-use technologies: current state, remaining challenges, and future development

JJ Samaras, M Micheletti, W Ding - Annual Review of Chemical …, 2022 - annualreviews.org
Single-use technologies have transformed conventional biopharmaceutical manufacturing,
and their adoption is increasing rapidly for emerging applications like antibody–drug …

Systematic evaluation of high-throughput scale-down models for single-use bioreactors (SUB) using volumetric gas flow rate as the criterion

X Zhang, J Moroney, L Hoshan, R Jiang… - Biochemical Engineering …, 2019 - Elsevier
Develo** representative bioreactor scale-down models is a critical part in process
development and characterization. Here we present a systematic analysis of high …

How to produce mAbs in a cube-shaped stirred single-use bioreactor at 200 L scale

C Schirmer, J Müller, N Steffen, S Werner… - … : methods and protocols, 2020 - Springer
Single-use bioreactors have increasingly been used in recent years, for both research and
development as well as industrial production, especially in mammalian cell-based …

Development, Characterization, and Optimization of a Multi-Chamber, Single-Use Bioreactor

M Amer - 2019 - search.proquest.com
Stirred-tank single-use bioreactors have proven their capability to successfully replace their
stainless-steel counterparts in the biopharmaceutical industry. To date, however, only a five …