Hormone secretion is highly organized temporally, achieving optimal biological functioning
and health. The master clock located in the suprachiasmatic nucleus (SCN) of the …

Although most cases of short stature associated with growth hormone (GH) deficiency are
sporadic and idiopathic, some 5-30% have an affected first degree relative consistent with a …

Chicken growth hormone (cGH), a polypeptide hormone synthesized in and secreted by the
pituitary gland, is involved in a wide variety of physiological functions such as growth, body …

To provide an animal model of central hypothyroidism, mice deficient in the TRH-receptor 1
(TRH-R1) gene were generated by homologous recombination. The pituitaries of TRH …

Estrogens are essential for female reproduction and overall well-being, and estrogens in the
circulation are largely synthesized in ovarian granulosa cells. Using primary cultures of …

This report describes the development and validation of the rGHp-Cre transgenic mouse that
allows for selective Cre-mediated recombination of loxP-modified alleles in the GH …

Genetic evidence from patients with mutations of the thyroid hormone receptor α gene
(THRA) indicates that the dominant negative activity of mutants underlies the pathological …

A total of 142 chicken blood samples were collected and a specific primer set was used to
amplify a fragment of growth hormone locus using PCR. PCR products were digested with …

Growth hormone (GH) belongs to a family of pituitary hormones together with prolactin and
somatolactin. In our previous study, GH and its cDNA were identified in the pituitary gland of …

Mutations of the thyroid hormone receptor α gene (THRA) cause hypothyroidism in patients
with growth and developmental retardation, and skeletal dysplasia. Genetic evidence …