Mutations in G protein–coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches
There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …
these membrane receptors members of the most abundant gene family in the human …
The expanding therapeutic perspective of CCR5 blockade
L Vangelista, S Vento - Frontiers in immunology, 2018 - frontiersin.org
CCR5 and its interaction with chemokine ligands have been crucial for understanding and
tackling HIV-1 entry into target cells. However, over time, CCR5 has witnessed an …
tackling HIV-1 entry into target cells. However, over time, CCR5 has witnessed an …
CCR5 is a receptor for Staphylococcus aureus leukotoxin ED
Pore-forming toxins are critical virulence factors for many bacterial pathogens and are
central to Staphylococcus aureus-mediated killing of host cells. S. aureus encodes pore …
central to Staphylococcus aureus-mediated killing of host cells. S. aureus encodes pore …
Chemokine receptor CCR5: from AIDS to atherosclerosis
KL Jones, JJ Maguire… - British journal of …, 2011 - Wiley Online Library
There is increasing recognition of an important contribution of chemokines and their
receptors in the pathology of atherosclerosis and related cardiovascular disease. The …
receptors in the pathology of atherosclerosis and related cardiovascular disease. The …
A Novel CCR5 Mutation Common in Sooty Mangabeys Reveals SIVsmm Infection of CCR5-Null Natural Hosts and Efficient Alternative Coreceptor Use In Vivo
NE Riddick, EA Hermann, LM Loftin, ST Elliott… - PLoS …, 2010 - journals.plos.org
In contrast to HIV infection in humans and SIV in macaques, SIV infection of natural hosts
including sooty mangabeys (SM) is non-pathogenic despite robust virus replication. We …
including sooty mangabeys (SM) is non-pathogenic despite robust virus replication. We …
Microorganisms as shapers of human civilization, from pandemics to even our genomes: villains or friends? A Historical approach
Universal history is characterized by continuous evolution, in which civilizations are born
and die. This evolution is associated with multiple factors, among which the role of …
and die. This evolution is associated with multiple factors, among which the role of …
Palaeopathology: Current challenges and medical impact
Palaeopathology is the science which studies ancient human diseases. Throughout its
relatively young history it underwent tremendous technological and methodological …
relatively young history it underwent tremendous technological and methodological …
CCR5 and CCR5Δ32 in bacterial and parasitic infections: Thinking chemokine receptors outside the HIV box
The CCR5 molecule was reported in 1996 as the main HIV‐1 co‐receptor. In that same year,
the CCR5Δ32 genetic variant was described as a strong protective factor against HIV‐1 …
the CCR5Δ32 genetic variant was described as a strong protective factor against HIV‐1 …
Modulating vertebrate physiology by genomic fine-tuning of GPCR functions
T Schöneberg - Physiological Reviews, 2025 - journals.physiology.org
G protein-coupled receptors (GPCRs) play a crucial role as membrane receptors, facilitating
the communication of eukaryotic species with their environment and regulating cellular and …
the communication of eukaryotic species with their environment and regulating cellular and …
[HTML][HTML] G protein-coupled time travel: evolutionary aspects of GPCR research
The common seven-transmembrane–domain (TMD) architecture of G protein–coupled
receptors (GPCRs) has been preserved over a vast period of time, and highly conserved …
receptors (GPCRs) has been preserved over a vast period of time, and highly conserved …