The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Simple Summary Lung cancer remains the most commonly diagnosed cancer in the United
States, only behind sex-specific cancers such as breast and prostate cancer. While not a sex …

Reproductive hormones play a crucial role in the growth and maintenance of the
mammalian skeleton. Indeed, the biological significance for this hormonal regulation of …

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal
antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) …

The use of genetically manipulated mouse models, gene and protein discovery and the
cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal …

Sex steroids are chief regulators of gender differences in the skeleton, and male gender is
one of the strongest protective factors against osteoporotic fractures. This advantage in bone …

Bone is a dynamic organ constantly remodeled to support calcium homeostasis and
structural needs. The osteoclast is the cell responsible for removing both the organic and …

Traditional textbook physiology has ascribed unitary functions to hormones from the anterior
and posterior pituitary gland, mainly in the regulation of effector hormone secretion from …

Male osteoporosis is a still largely underdiagnosed pathological condition. As a
consequence, bone fragility in men remains undertreated mainly due to the low screening …

The past decade has seen significant advances in our understanding of skeletal
homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent …