Surface engineering on bacteria for tumor immunotherapy: strategies and perspectives

L Fu, Q He, X Lu, L Hu, H Qian… - Advanced Functional …, 2024 - Wiley Online Library
Bacteria have garnered significant attention in tumor immunotherapy recently years, owing
to their immune‐activating properties, ease of genetic manipulation, and colonization …

Bacterial therapies at the interface of synthetic biology and nanomedicine

J Hahn, S Ding, J Im, T Harimoto, KW Leong… - Nature Reviews …, 2024 - nature.com
Bacteria are emerging as living drugs to treat a broad range of disease indications.
However, the inherent advantages of these replicating and immunostimulatory therapies …

Nanozyme‐Coated Bacteria Hitchhike on CD11b+ Immune Cells to Boost Tumor Radioimmunotherapy

H Li, P Pei, Q He, X Dong, C Zhang, W Shen… - Advanced …, 2024 - Wiley Online Library
Bacterial‐based delivery strategies have recently emerged as a unique research direction in
the field of drug delivery. However, bacterial vectors are quickly phagocytosed by immune …

Biomaterials to regulate tumor extracellular matrix in immunotherapy

Y Zhang, X Dong, Y Zhang, Z Chen, G Zhou… - Journal of Controlled …, 2024 - Elsevier
The tumor extracellular matrix (ECM) provides physical support and influences tumor
development, metastasis, and the tumor microenvironment, creating barriers to immune drug …

Engineered bacteria breach tumor physical barriers to enhance radio-immunotherapy

Y Zhang, Y Liu, T Li, X Yang, S Lang, P Pei… - Journal of Controlled …, 2024 - Elsevier
Radiotherapy widely applied for local tumor therapy in clinic has been recently reinvigorated
by the discovery that radiotherapy could activate systematic antitumor immune response …

Harnessing and mimicking bacterial features to combat cancer: from living entities to artificial mimicking systems

P Gao, Z Duan, G Xu, Q Gong, J Wang… - Advanced …, 2024 - Wiley Online Library
Bacterial‐derived micro‐/nanomedicine has garnered considerable attention in anticancer
therapy, owing to the unique natural features of bacteria, including specific targeting ability …

Bacteria and bacterial components as natural bio-Nanocarriers for drug and gene delivery Systems in Cancer Therapy

R Zong, H Ruan, C Liu, S Fan, J Li - Pharmaceutics, 2023 - mdpi.com
Bacteria and bacterial components possess multifunctional properties, making them
attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent …

Bacteria-driven bio-therapy: from fundamental studies to clinical trials

Y Yu, S Lin, Z Chen, B Qin, Z He, M Cheng, M Sun… - Nano Today, 2023 - Elsevier
Natural bacteria have been utilized to directly maintain the human body's homeostasis for
directly or indirectly relieving diseases throughout history. With the rapid development of …

Microbiome in radiotherapy: an emerging approach to enhance treatment efficacy and reduce tissue injury

L Lu, F Li, Y Gao, S Kang, J Li, J Guo - Molecular Medicine, 2024 - Springer
Radiotherapy is a widely used cancer treatment that utilizes powerful radiation to destroy
cancer cells and shrink tumors. While radiation can be beneficial, it can also harm the …

Nano-armor modification of bacteria through supramolecular interactions for disease treatment

X Cao, Y Wang, Q Wang, H Yang, Y Ding… - Coordination Chemistry …, 2024 - Elsevier
Research on nano-armored bacterial materials (NABM) has attracted considerable attention
because of their ability to exert synergistic effects on bacteria and nanomaterials through …