Cancer stem cells (CSCs) are a distinct subpopulation of tumor cells with stem cell-like
features. Able to initiate and sustain tumor growth and mostly resistant to anti-cancer …

The human skeleton, made of 206 bones, plays vital roles including supporting the body,
protecting organs, enabling movement, and storing minerals. Bones are made of organic …

Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts
produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be …

Iron is an essential element for proper functioning of cells within mammalian organ systems;
in particular, iron homeostasis is critical for joint health. Excess iron can induce oxidative …

The paper presents the current understanding on the effects of five metals on bone tissue,
namely iron, zinc, copper, cadmium, and mercury. Iron, zinc, and copper contribute …

Diseases/conditions with diverse etiology, such as hemoglobinopathies, hereditary
hemochromatosis and menopause, could lead to chronic iron accumulation. This condition …

Iron is one of the important trace elements in life activities. Abnormal iron metabolism
increases the incidence of many skeletal diseases, especially for osteoporosis. Iron …

Background Numerous studies have demonstrated that iron overload is a risk factor of
osteoporosis. However, there has been no systematic and in-depth studies on the effect of …

Well-controlled iron levels are indispensable for health. Iron deficiency is the most common
cause of anemia, whereas iron overload, either hereditary or secondary due to disorders of …

Iron overload has been found very common in diseases such as hereditary
hemochromatosis, thalassemia, and sickle cell disease and in healthy postmenopausal …