Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace.“Alive, with good vision and no comorbidity”

FL Munier, M Beck-Popovic, GL Chantada… - Progress in retinal and …, 2019 - Elsevier
Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to
preserve life, with ocular survival, visual preservation and quality of life as secondary aims …

Pediatric cancer predisposition and surveillance: an overview, and a tribute to Alfred G. Knudson Jr

GM Brodeur, KE Nichols, SE Plon, JD Schiffman… - Clinical Cancer …, 2017 - AACR
The prevalence of childhood cancer attributable to genetic predisposition was generally
considered very low. However, recent reports suggest that at least 10% of pediatric cancer …

Childhood and adolescent cancer statistics, 2014

E Ward, C DeSantis, A Robbins… - CA: a cancer journal …, 2014 - Wiley Online Library
In this article, the American Cancer Society provides estimates of the number of new cancer
cases and deaths for children and adolescents in the United States and summarizes the …

Retinoblastoma

C Rodriguez-Galindo, DB Orbach… - Pediatric …, 2015 - pediatric.theclinics.com
Retinoblastoma is the most common neoplasm of the eye in childhood, representing 2.5% to
4% of all pediatric cancers. The average age-adjusted incidence rate of retinoblastoma in …

Second nonocular tumors among survivors of retinoblastoma treated with contemporary photon and proton radiotherapy

RV Sethi, HA Shih, BY Yeap, KW Mouw, R Petersen… - Cancer, 2014 - Wiley Online Library
BACKGROUND The leading cause of death among patients with hereditary retinoblastoma
is second malignancy. Despite its high rate of efficacy, radiotherapy (RT) is often avoided …

Proton therapy in children: a systematic review of clinical effectiveness in 15 pediatric cancers

R Leroy, N Benahmed, F Hulstaert… - International Journal of …, 2016 - Elsevier
Because it spares many normal tissues and reduces the integral dose, proton therapy (PT) is
the preferred tumor irradiation technique for treating childhood cancer. However, to the best …

Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy

JR Wong, LM Morton, MA Tucker… - Journal of Clinical …, 2014 - ascopubs.org
Purpose Hereditary retinoblastoma (Rb) survivors have increased risk of subsequent
malignant neoplasms (SMNs). Previous studies reported elevated radiotherapy (RT)-related …

Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p

W Wu, Y Qin, Z Li, J Dong, J Dai, C Lu… - Human …, 2013 - academic.oup.com
STUDY QUESTION What is the profile of miRNAs in seminal plasma of patients with non-
obstructive azoospermia (NOA)? SUMMARY ANSWER miR-141, miR-429 and miR-7-1-3p …

Secondary malignancies in pediatric cancer survivors: perspectives and review of the literature

DK Choi, I Helenowski, N Hijiya - International journal of cancer, 2014 - Wiley Online Library
With continuing improvements in the successful treatment of pediatric malignancies, long
term survivors of pediatric cancers and their providers are faced with new oncologic issues …

[HTML][HTML] Retinoblastoma for pediatric ophthalmologists

A AlAli, S Kletke, B Gallie, WC Lam - Asia-Pacific journal of ophthalmology, 2018 - Elsevier
Retinoblastoma can present in 1 or both eyes and is the most common intraocular
malignancy in childhood. It is typically initiated by biallelic mutation of the RB1 tumor …