The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Cancer is one of the greatest public health challenges. According to the World Health
Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most …

Wie kommunizieren Zellen? Was steuert die Aktivität von Zellen oder Enzymen? Wie verläuft
die Enstehung einer Krebszelle? Diese und ähnliche Fragen sind zentraler Gegenstand der …

Wnt/β-catenin signalling plays essential roles in embryonic development as well as tissue
homoeostasis in adults. Thus abnormal regulation of Wnt/β-catenin signalling is linked to a …

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

Wnt5a is a representative ligand that activates the β‐catenin‐independent pathways.
Because the β‐catenin‐independent pathway includes multiple signalling cascades in …

Wnts compromise a large family of secreted, hydrophobic glycoproteins that control a variety
of developmental and adult processes in all metazoan organisms. Recent advances in the …

Ubiquitination plays a major role in protein degradation. Although phosphorylation-
dependent ubiquitination is well known for the regulation of protein stability, methylation …

WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various
cellular processes. While WNT ligands usually signal through their dedicated Frizzled …

Mammalian skin and its appendages constitute the integumentary system forming a barrier
between the organism and its environment. During development, skin epidermal cells divide …