Intracellular cargo transport by kinesin-3 motors
Intracellular transport along microtubules enables cellular cargoes to efficiently reach the
extremities of large, eukaryotic cells. While it would take more than 200 years for a small …
extremities of large, eukaryotic cells. While it would take more than 200 years for a small …
Spatial regulation of microtubule-dependent transport by septin GTPases
The intracellular long-range transport of membrane vesicles and organelles is mediated by
microtubule motors (kinesins, dynein) which move cargo with spatiotemporal accuracy and …
microtubule motors (kinesins, dynein) which move cargo with spatiotemporal accuracy and …
Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms
The kinesin-3 motor KIF1A functions in neurons, where its fast and superprocessive motility
facilitates long-distance transport, but little is known about its force-generating properties …
facilitates long-distance transport, but little is known about its force-generating properties …
Cryo-EM unveils kinesin KIF1A's processivity mechanism and the impact of its pathogenic variant P305L
MPMH Benoit, L Rao, AB Asenjo, A Gennerich… - Nature …, 2024 - nature.com
Mutations in the microtubule-associated motor protein KIF1A lead to severe neurological
conditions known as KIF1A-associated neurological disorders (KAND). Despite insights into …
conditions known as KIF1A-associated neurological disorders (KAND). Despite insights into …
A structural model for microtubule minus-end recognition and protection by CAMSAP proteins
J Atherton, K Jiang, MM Stangier, Y Luo… - Nature structural & …, 2017 - nature.com
CAMSAP and Patronin family members regulate microtubule minus-end stability and
localization and thus organize noncentrosomal microtubule networks, which are essential …
localization and thus organize noncentrosomal microtubule networks, which are essential …
[HTML][HTML] A kinesin-1 variant reveals motor-induced microtubule damage in cells
Kinesins drive the transport of cellular cargoes as they walk along microtubule tracks;
however, recent work has suggested that the physical act of kinesins walking along …
however, recent work has suggested that the physical act of kinesins walking along …
Building sensory axons: Delivery and distribution of NaV1.7 channels and effects of inflammatory mediators
Sodium channel NaV1. 7 controls firing of nociceptors, and its role in human pain has been
validated by genetic and functional studies. However, little is known about NaV1. 7 …
validated by genetic and functional studies. However, little is known about NaV1. 7 …
PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
N Siddiqui, AJ Zwetsloot, A Bachmann, D Roth… - Nature …, 2019 - nature.com
The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core
vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the …
vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the …
KIF1A is kinetically tuned to be a superengaging motor under hindering loads
KIF1A is a highly processive vesicle transport motor in the kinesin-3 family. Mutations in
KIF1A lead to neurodegenerative diseases including hereditary spastic paraplegia. We …
KIF1A lead to neurodegenerative diseases including hereditary spastic paraplegia. We …
Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A
D Cong, J Ren, Y Zhou, S Wang, J Liang, M Ding… - PLoS …, 2021 - journals.plos.org
The UNC-104/KIF1A motor is crucial for axonal transport of synaptic vesicles, but how the
UNC-104/KIF1A motor is activated in vivo is not fully understood. Here, we identified point …
UNC-104/KIF1A motor is activated in vivo is not fully understood. Here, we identified point …