Neuroinflammation constitutes a fundamental process involved in the progression of several
neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease …

Although an extensive body of literature confirmed γ-aminobutyric acid (GABA) as mediator
within the enteric nervous system (ENS) controlling gastrointestinal (GI) function, the true …

Objectives Evidence-based medicine suggests that schizophrenia is associated with an
inflammatory syndrome, but the extent to which this syndrome is normalized by antipsychotic …

Bidirectional interactions between the immune and the nervous systems are of considerable
interest both for deciphering their functioning and for designing novel therapeutic strategies …

Emerging evidence has demonstrated that CD4+ T cells infiltrate into the substantia nigra
(SN) in Parkinson's disease (PD) patients and in animal models of PD. SN-infiltrated CD4+ T …

Pain perception involves current stimulation in peripheral nociceptive nerves and the
subsequent stimulation of postsynaptic excitatory neurons in the spinal cord. Importantly, in …

Background Hypothetically, psychotic disorders could be caused or conditioned by
immunological mechanisms. If so, one might expect there to be peripheral immune system …

Frequent diseases of the CNS, such as Alzheimer's disease, Parkinson's disease, multiple
sclerosis, and psychiatric disorders (eg, schizophrenia), elicit a neuroinflammatory response …

Dendritic cells (DCs) are responsible for priming T cells and for promoting their
differentiation from naive T cells into appropriate effector cells. Emerging evidence suggests …

Rationale There is a substantial unmet need for biomarkers to predict treatment response in
major depressive disorder (MDD). Evidence has converged on activation of the inflammatory …