A giant molecular proton pump: structure and mechanism of respiratory complex I

LA Sazanov - Nature reviews Molecular cell biology, 2015 - nature.com
The mitochondrial respiratory chain, also known as the electron transport chain (ETC), is
crucial to life, and energy production in the form of ATP is the main mitochondrial function …

Molecular aspects of bacterial pH sensing and homeostasis

TA Krulwich, G Sachs, E Padan - Nature Reviews Microbiology, 2011 - nature.com
Diverse mechanisms for pH sensing and cytoplasmic pH homeostasis enable most bacteria
to tolerate or grow at external pH values that are outside the cytoplasmic pH range they must …

Structure of the membrane domain of respiratory complex I

RG Efremov, LA Sazanov - Nature, 2011 - nature.com
Complex I is the first and largest enzyme of the respiratory chain, coupling electron transfer
between NADH and ubiquinone to the translocation of four protons across the membrane. It …

[HTML][HTML] Regulation of CO2 Concentrating Mechanism in Cyanobacteria

RL Burnap, M Hagemann, A Kaplan - Life, 2015 - mdpi.com
In this chapter, we mainly focus on the acclimation of cyanobacteria to the changing ambient
CO2 and discuss mechanisms of inorganic carbon (Ci) uptake, photorespiration, and the …

Mrp antiporters have important roles in diverse bacteria and archaea

M Ito, M Morino, TA Krulwich - Frontiers in microbiology, 2017 - frontiersin.org
Mrp (M ultiple r esistance and p H) antiporter was identified as a gene complementing an
alkaline-sensitive mutant strain of alkaliphilic Bacillus halodurans C-125 in 1990. At that …

Structure of an ancient respiratory system

H Yu, CH Wu, GJ Schut, DK Haja, G Zhao, JW Peters… - Cell, 2018 - cell.com
Hydrogen gas-evolving membrane-bound hydrogenase (MBH) and quinone-reducing
complex I are homologous respiratory complexes with a common ancestor, but a structural …

Nature and bioprospecting of haloalkaliphilics: a review

G Uma, MM Babu, VSG Prakash, SJ Nisha… - World Journal of …, 2020 - Springer
The haloalkaliphilics are an important subset of extremophiles that grow in salt [upto
33%(wt/vol) NaCl] and alkaline pH (> 9). They are found in hypersaline environments …

Improved Salt Tolerance and Metabolomics Analysis of Synechococcus elongatus UTEX 2973 by Overexpressing Mrp Antiporters

J Cui, T Sun, S Li, Y **e, X Song, F Wang… - … in Bioengineering and …, 2020 - frontiersin.org
The fast-growing cyanobacterium Synechococcus elongatus UTEX 2973 (Syn2973) is a
promising candidate for photosynthetic microbial factory. Seawater utilization is necessary …

Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter

J Steiner, L Sazanov - Elife, 2020 - elifesciences.org
Multiple resistance and pH adaptation (Mrp) antiporters are multi-subunit Na+ (or K+)/H+
exchangers representing an ancestor of many essential redox-driven proton pumps, such as …

Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life

H Yu, DK Haja, GJ Schut, CH Wu, X Meng… - Nature …, 2020 - nature.com
Modern day aerobic respiration in mitochondria involving complex I converts redox energy
into chemical energy and likely evolved from a simple anaerobic system now represented by …