An overview of advancement of organoruthenium (II) complexes as prospective anticancer agents

M Bashir, IA Mantoo, F Arjmand, S Tabassum… - Coordination Chemistry …, 2023 - Elsevier
The successful clinical translation of platinum drugs for cancer treatment has witnessed an
upsurge in the development of metal compounds as therapeutics and diagnostics drugs …

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

Investigation into antiproliferative activity and apoptosis mechanism of new arene Ru (ii) carbazole-based hydrazone complexes

TS Kamatchi, MKM Subarkhan, R Ramesh… - Dalton …, 2020 - pubs.rsc.org
Ruthenium complexes with bioactive ligands are becoming promising substitutes for
platinum complexes due to their precise action against various cancers. In the present study …

Synthesis and Structure of Arene Ru(II) NO-Chelating Complexes: In Vitro Cytotoxicity and Cancer Cell Death Mechanism

S Balaji, MK Mohamed Subarkhan, R Ramesh… - …, 2020 - ACS Publications
A panel of six new structurally related organometallic arene Ru (II) complexes of general
composition [(η6-benzene) Ru (L) Cl](1–3) and [(η6-p-cymene) Ru (L) Cl](4–6)(L …

Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers

AMS El-Sharief, YA Ammar, A Belal… - Bioorganic …, 2019 - Elsevier
Abstract Reaction of 5-morphilinosulfonylisatin (1) with acetophenones (2a–e) afforded 3-
hydroxy-3-substituted-2-oxoindoles 3a-e, when treated with acetic acid the expected 3 …

Recent advances in anticancer ruthenium Schiff base complexes

S Parveen - Applied Organometallic Chemistry, 2020 - Wiley Online Library
Nowadays in cancer treatment, both metal complexes and organic molecules are being
widely used. Current years have seen a surge of interest in the application of organometallic …

[HTML][HTML] Research progress on the biological activities of metal complexes bearing polycyclic aromatic hydrazones

R Liu, J Cui, T Ding, Y Liu, H Liang - Molecules, 2022 - mdpi.com
Due to the abundant and promising biological activities of aromatic hydrazones, it is of great
significance to study the biological activities of their metal complexes for the research and …

In vitro evaluations of biomolecular interactions, antioxidant and anticancer activities of Nickel (II) and Copper (II) complexes with 1: 2 coordination of anthracenyl …

KS Neethu, S Sivaselvam, M Theetharappan… - Inorganica Chimica …, 2021 - Elsevier
A set of nickel (II) and copper (II) complexes incorporated anthracenyl hydrazone ligands
were synthesized and characterized with the help of various spectroscopic techniques …

Impact of biphenyl benzhydrazone-incorporated arene Ru (II) complexes on cytotoxicity and the cancer cell death mechanism

A Arunachalam, R Rengan, D Umapathy… - …, 2022 - ACS Publications
The biological efficacy of arene ruthenium complexes is currently of great interest due to the
significance of arene moieties, chelates, and metal centers in defining and controlling their …

A review of hydrazide-hydrazone metal complexes' antitumor potential

N Ribeiro, I Correia - Frontiers in Chemical Biology, 2024 - frontiersin.org
Cancer inflicts a tremendous burden on modern society, and more effective and selective
treatments need to be developed. Metallodrugs have been extensively explored as …