Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

The mechanistic target of rapamycin (mTOR) has gathered significant attention as a
ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation …

Lysosomes have been classically considered terminal degradative organelles, but in recent
years they have been found to participate in many other cellular processes, including killing …

Integrins are a family of transmembrane cell surface molecules that constitute the principal
adhesion receptors for the extracellular matrix (ECM) and are indispensable for the …

The exocyst is an octameric protein complex that is implicated in the tethering of secretory
vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal …

The dissemination of cancer cells from the primary tumor to a distant site, known as
metastasis, is the main cause of mortality in cancer patients. Metastasis is a very complex …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Integrin-containing focal adhesions transmit extracellular signals across the plasma
membrane to modulate cell adhesion, signalling and survival. Although integrins are known …