Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

The dramatic increase in modern lifestyle diseases such as cancer, cardiovascular diseases
and diabetes has renewed researchers' interest to explore nature as a source of novel …

Metformin is a first-line drug for the treatment of individuals with type 2 diabetes, yet its
precise mechanism of action remains unclear. Metformin exerts its antihyperglycemic action …

Metformin, the universal first-line treatment for type 2 diabetes, exerts its therapeutic glucose-
lowering effects by inhibiting hepatic gluconeogenesis. However, the primary molecular …

AMP-activated protein kinase (AMPK) senses energetic stress and, in turn, promotes
catabolic and suppresses anabolic metabolism coordinately to restore energy balance. We …

5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most
commonly used pharmacological modulators of AMPK activity. The majority of early studies …

Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently
the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the …

Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) is a key player in
regulating energy metabolism, placing it at the center stage in studies of diabetes and …

The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status
that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP: ATP …

Dysfunctional mTORC1 signaling is associated with a number of human pathologies owing
to its central role in controlling cell growth, proliferation, and metabolism. Regulation of …