The potential and challenges of nanopore sequencing

D Branton, DW Deamer, A Marziali, H Bayley… - Nature …, 2008 - nature.com
A nanopore-based device provides single-molecule detection and analytical capabilities
that are achieved by electrophoretically driving molecules in solution through a nano-scale …

Nanopore analytics: sensing of single molecules

S Howorka, Z Siwy - Chemical Society Reviews, 2009 - pubs.rsc.org
In nanopore analytics, individual molecules pass through a single nanopore giving rise to
detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore …

Detection of nucleic acids with graphene nanopores: ab initio characterization of a novel sequencing device

T Nelson, B Zhang, OV Prezhdo - Nano letters, 2010 - ACS Publications
We report an ab initio density functional theory study of the interaction of four nucleobases,
cytosine, thymine, adenine, and guanine, with a novel graphene nanopore device for …

Electronic signatures of all four DNA nucleosides in a tunneling gap

S Chang, S Huang, J He, F Liang, P Zhang, S Li… - Nano …, 2010 - ACS Publications
Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of
sub-millisecond duration with a broad distribution of peak currents. This distribution narrows …

Two-dimensional nanopores and nanoporous membranes for ion and molecule transport

G Danda, M Drndić - Current opinion in biotechnology, 2019 - Elsevier
Highlights•Nanopore and nanoporous devices can be used for molecule detection and
filtration.•Two-dimensional (2D) membranes can enhance sensing sensitivity and molecular …

Controlled translocation of individual DNA molecules through protein nanopores with engineered molecular brakes

M Rincon-Restrepo, E Mikhailova, H Bayley… - Nano …, 2011 - ACS Publications
Protein nanopores may provide a cheap and fast technology to sequence individual DNA
molecules. However, the electrophoretic translocation of ssDNA molecules through protein …

Effects of self-interaction corrections on the transport properties of phenyl-based molecular junctions

C Toher, S Sanvito - Physical Review B—Condensed Matter and Materials …, 2008 - APS
In transport calculations for molecular junctions based on density-functional theory, the
choice of exchange and correlation functional may dramatically affect the results. In …

Electrical conductance in biological molecules

M Waleed Shinwari, M Jamal Deen… - Advanced Functional …, 2010 - Wiley Online Library
Nucleic acids and proteins are not only biologically important polymers. They have recently
been recognized as novel functional materials surpassing conventional materials in many …

Electrochemical tunnelling sensors and their potential applications

T Albrecht - Nature communications, 2012 - nature.com
The quantum-mechanical tunnelling effect allows charge transport across nanometre-scale
gaps between conducting electrodes. Application of a voltage between these electrodes …

Threading DNA through nanopores for biosensing applications

M Fyta - Journal of physics: condensed Matter, 2015 - iopscience.iop.org
This review outlines the recent achievements in the field of nanopore research. Nanopores
are typically used in single-molecule experiments and are believed to have a high potential …