The potential and challenges of nanopore sequencing
A nanopore-based device provides single-molecule detection and analytical capabilities
that are achieved by electrophoretically driving molecules in solution through a nano-scale …
that are achieved by electrophoretically driving molecules in solution through a nano-scale …
Nanopore analytics: sensing of single molecules
In nanopore analytics, individual molecules pass through a single nanopore giving rise to
detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore …
detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore …
Detection of nucleic acids with graphene nanopores: ab initio characterization of a novel sequencing device
We report an ab initio density functional theory study of the interaction of four nucleobases,
cytosine, thymine, adenine, and guanine, with a novel graphene nanopore device for …
cytosine, thymine, adenine, and guanine, with a novel graphene nanopore device for …
Electronic signatures of all four DNA nucleosides in a tunneling gap
Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of
sub-millisecond duration with a broad distribution of peak currents. This distribution narrows …
sub-millisecond duration with a broad distribution of peak currents. This distribution narrows …
Two-dimensional nanopores and nanoporous membranes for ion and molecule transport
Highlights•Nanopore and nanoporous devices can be used for molecule detection and
filtration.•Two-dimensional (2D) membranes can enhance sensing sensitivity and molecular …
filtration.•Two-dimensional (2D) membranes can enhance sensing sensitivity and molecular …
Controlled translocation of individual DNA molecules through protein nanopores with engineered molecular brakes
M Rincon-Restrepo, E Mikhailova, H Bayley… - Nano …, 2011 - ACS Publications
Protein nanopores may provide a cheap and fast technology to sequence individual DNA
molecules. However, the electrophoretic translocation of ssDNA molecules through protein …
molecules. However, the electrophoretic translocation of ssDNA molecules through protein …
Effects of self-interaction corrections on the transport properties of phenyl-based molecular junctions
In transport calculations for molecular junctions based on density-functional theory, the
choice of exchange and correlation functional may dramatically affect the results. In …
choice of exchange and correlation functional may dramatically affect the results. In …
Electrical conductance in biological molecules
Nucleic acids and proteins are not only biologically important polymers. They have recently
been recognized as novel functional materials surpassing conventional materials in many …
been recognized as novel functional materials surpassing conventional materials in many …
Electrochemical tunnelling sensors and their potential applications
T Albrecht - Nature communications, 2012 - nature.com
The quantum-mechanical tunnelling effect allows charge transport across nanometre-scale
gaps between conducting electrodes. Application of a voltage between these electrodes …
gaps between conducting electrodes. Application of a voltage between these electrodes …
Threading DNA through nanopores for biosensing applications
M Fyta - Journal of physics: condensed Matter, 2015 - iopscience.iop.org
This review outlines the recent achievements in the field of nanopore research. Nanopores
are typically used in single-molecule experiments and are believed to have a high potential …
are typically used in single-molecule experiments and are believed to have a high potential …