Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

Right brain, left brain in depressive disorders: clinical and theoretical implications of behavioral, electrophysiological and neuroimaging findings

GE Bruder, JW Stewart, PJ McGrath - Neuroscience & Biobehavioral …, 2017 - Elsevier
The right and left side of the brain are asymmetric in anatomy and function. We review
electrophysiological (EEG and event-related potential), behavioral (dichotic and visual …

[HTML][HTML] Zuranolone in major depressive disorder: results from MOUNTAIN—a phase 3, multicenter, double-blind, randomized, placebo-controlled trial

AH Clayton, R Lasser, I Nandy, AJ Sankoh… - The Journal of …, 2023 - psychiatrist.com
Objective: To evaluate the efficacy and safety of zuranolone, an investigational neuroactive
steroid and GABA A receptor positive allosteric modulator, in major depressive disorder …

EEG resting-state large-scale brain network dynamics are related to depressive symptoms

A Damborská, MI Tomescu, E Honzírková… - Frontiers in …, 2019 - frontiersin.org
Background: The few previous studies on resting-state electroencephalography (EEG)
microstates in depressive patients suggest altered temporal characteristics of microstates …

Large-scale lesion symptom map** of depression identifies brain regions for risk and resilience

NT Trapp, JE Bruss, K Manzel, J Grafman, D Tranel… - Brain, 2023 - academic.oup.com
Understanding neural circuits that support mood is a central goal of affective neuroscience,
and improved understanding of the anatomy could inform more targeted interventions in …

Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder

CA Figueroa, J Cabral, RJT Mocking… - Human brain …, 2019 - Wiley Online Library
Neurobiological models to explain vulnerability of major depressive disorder (MDD) are
scarce and previous functional magnetic resonance imaging studies mostly examined …

Transdiagnostic prediction of affective, cognitive, and social function through brain reward anticipation in schizophrenia, bipolar disorder, major depression, and …

K Schwarz, C Moessnang, JI Schweiger… - Schizophrenia …, 2020 - academic.oup.com
The relationship between transdiagnostic, dimensional, and categorical approaches to
psychiatric nosology is under intense debate. To inform this discussion, we studied neural …

Personalized repetitive transcranial magnetic stimulation for depression

J Gogulski, JM Ross, A Talbot, CC Cline… - Biological Psychiatry …, 2023 - Elsevier
Personalized treatments are gaining momentum across all fields of medicine. Precision
medicine can be applied to neuromodulatory techniques, in which focused brain stimulation …

Experimental suppression of transcranial magnetic stimulation‐electroencephalography sensory potentials

JM Ross, M Sarkar, CJ Keller - Human Brain Map**, 2022 - Wiley Online Library
The sensory experience of transcranial magnetic stimulation (TMS) evokes cortical
responses measured in electroencephalography (EEG) that confound interpretation of TMS …

Attenuated intrinsic connectivity within cognitive control network among individuals with remitted depression: temporal stability and association with negative cognitive …

JP Stange, KL Bessette, LM Jenkins… - Human brain …, 2017 - Wiley Online Library
Many individuals with major depressive disorder (MDD) experience cognitive dysfunction
including impaired cognitive control and negative cognitive styles. Functional connectivity …