Metal–organic frameworks (MOFs) are a new class of porous crystalline materials
constructed from organic ligands and metal ions/clusters. Owing to their unique advantages …

The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

Although C–H functionalization is one of the simplest reactions, it requires the use of highly
active and selective catalysts. Recently, C–H-active transformations using porous materials …

Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Bimolecular homolytic substitution (SH2) is an open-shell mechanism that is implicated
across a host of biochemical alkylation pathways. Surprisingly, however, this radical …

Despite decades of ground-breaking research in academia, organic synthesis is still a rate-
limiting factor in drug-discovery projects. Here we present some current challenges in …

As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …

The direct functionalization of C (sp3)–H bonds represents one of the most investigated
approaches to develop new synthetic methodology. Among the available strategies for …