Background The usefulness of histidine-rich protein-2/3 (HRP2/3)-based rapid diagnostic
tests of malaria due to Plasmodium falciparum has been threatened by the appearance of …

Background Malaria rapid diagnostic tests based on histidine-rich protein-2 have played a
vital role in improving malaria case management and surveillance particularly in Africa …

In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …

MalariaGEN is a data-sharing network that enables groups around the world to work
together on the genomic epidemiology of malaria. Here we describe a new release of …

False-negative results for Plasmodium falciparum histidine-rich protein (HRP) 2–based
rapid diagnostic tests (RDTs) are increasing in Eritrea. We investigated HRP gene 2/3 …

Most rapid diagnostic tests for Plasmodium falciparum malaria target the Histidine-Rich
Proteins 2 and 3 (HRP2 and HRP3). Deletions of the hrp2 and hrp3 genes result in false …

Abstract Background Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are
often used to determine whether persons with fever should be treated with anti-malarials …

Deletions of the Plasmodium falciparum hrp2 and hrp3 genes can affect the performance of
HRP2-based malaria rapid diagnostic tests (RDTs). Such deletions have been reported from …

A better understanding of the drivers of the spread of malaria parasites and drug resistance
across space and time is needed. These drivers can be elucidated using genetic tools. Here …

Rapid diagnostic tests (RDTs) have transformed malaria diagnosis. The most prevalent P.
falciparum RDTs detect histidine-rich protein 2 (PfHRP2). However, pfhrp2 gene deletions …