Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

▪ Abstract Both physiological cell death (apoptosis) and, in some cases, accidental cell death
(necrosis) involve a two-step process. At a first level, numerous physiological and some …

Proteins requiring post‐translational modifications such as N‐linked glycosylation are
processed in the endoplasmic reticulum (ER). A diverse array of cellular stresses can lead to …

Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

BAX and BAK are “multidomain” proapoptotic proteins that initiate mitochondrial dysfunction
but also localize to the endoplasmic reticulum (ER). Mouse embryonic fibroblasts deficient …

The permeability transition (PT) denotes an increase of the mitochondrial inner membrane
permeability to solutes with molecular masses up to about 1500 Da. It is presumed to be …

Mammalian target of rapamycin (mTOR) is a kinase that functions as a master switch
between catabolic and anabolic metabolism and as such is a target for the design of …

Some time ago, I wrote a review entitled ''Uncoupling of respiration and phosphorylation''for
the wx book ''Frontier of Cellular Bioenergetics''1. In that Ž. paper I hypothesized that i the …

Death of hepatocytes and other hepatic cell types is a characteristic feature of liver diseases
as diverse as cholestasis, viral hepatitis, ischemia/reperfusion, liver preservation for …