Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

NF-κB-inducing kinase (NIK), the essential upstream kinase, which regulates activation of
the noncanonical NF-κB pathway, has important roles in regulating immunity and …

The development of pancreatic cancer requires the acquisition of oncogenic KRas mutations
and upregulation of growth factor signaling, but the relationship between these is not well …

Macrophages are attracted to develo** tumors and can participate in immune surveillance
to eliminate neoplastic cells. In response, neoplastic cells utilize NF-κB to suppress this …

Abstract Tumor Necrosis Factor (TNF) is a potent inflammatory cytokine that exerts its
functions through the activation of two distinct receptors, TNFR1 and TNFR2. Both receptors …

The noncanonical NFκB signaling pathway mediates the biological functions of diverse cell
survival, growth, maturation, and differentiation factors that are important for the …

Abstract Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, and in spite of
intense efforts there are limited therapeutic options for patients with PDAC. PDACs harbor a …

In addition to regulating immune responses, the NF-κB family of transcription factors also
promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have …

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic
adaptor proteins regulate the signal transduction pathways of a variety of receptors …