Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain.
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …

Epilepsy is broadly characterized by aberrant neuronal excitability. Glutamate is the
predominant excitatory neurotransmitter in the adult mammalian brain; thus, much of past …

Sciatic nerve injury has been used for over a century to investigate the process of nerve
damage, to assess the absolute and relative capacity of the central and peripheral nervous …

Anxiety disorders are frequent, though probably underdiagnosed, comorbidities in epilepsy.
Epilepsy and anxiety may share common neurobiological correlates as shown in animal …

Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

Dysregulation of glutamate homeostasis is a well-established core feature of
neuropsychiatric disorders. Extracellular glutamate concentration is regulated by glutamate …

Epilepsy is associated with substantial neuropsychiatric impairments that persist long after
the onset of the condition, significantly impacting quality of life. The goal of this review was to …

Despite new antiseizure medications, the development of cholinergic‐induced refractory
status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to …

The initiation and maintenance of cholinergic-induced status epilepticus (SE) are associated
with decreased synaptic gamma-aminobutyric acid A receptors (GABA AR) and increased N …

The objective of this study was to explore the association between the P2X7 purinergic
receptor (P2X7R) and neuroinflammation using a preclinical model of acute bipolar mania …